ID   ENV_DHVI1               Reviewed;         521 AA.
AC   P27427;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   02-JUN-2021, entry version 66.
DE   RecName: Full=Envelope glycoprotein;
DE   Flags: Precursor;
GN   Name=P4;
OS   Dhori virus (strain Indian/1313/61) (Dho).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Thogotovirus.
OX   NCBI_TaxID=11319;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=6935; Ixodida (ticks).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2309437; DOI=10.1016/0042-6822(90)90181-p;
RA   Freedman-Faulstich E.Z., Fuller F.J.;
RT   "Nucleotide sequence of the tick-borne, orthomyxo-like Dhori/Indian/1313/61
RT   virus envelope gene.";
RL   Virology 175:10-18(1990).
CC   -!- FUNCTION: Attaches the virus to host cellular receptor and later
CC       induces fusion of virion with host membrane. {ECO:0000305}.
CC   -!- SUBUNIT: Homooligomer; disulfide-linked (possibly homodimer).
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}.
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DR   EMBL; M34002; AAA47907.1; -; Genomic_RNA.
DR   PIR; A34679; VGIVDH.
DR   PDB; 5XEB; X-ray; 2.50 A; A/B/C=21-494.
DR   PDBsum; 5XEB; -.
DR   SMR; P27427; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR   InterPro; IPR004955; Baculovirus_Gp64.
DR   Pfam; PF03273; Baculo_gp64; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Glycoprotein; Membrane; Signal;
KW   Transmembrane; Transmembrane helix; Virion.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..521
FT                   /note="Envelope glycoprotein"
FT                   /id="PRO_0000039174"
FT   TRANSMEM        501..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        396
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   STRAND          45..59
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          64..78
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          87..94
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   HELIX           99..108
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          111..113
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          117..121
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   HELIX           124..129
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          136..139
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          154..168
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          173..179
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          181..186
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          192..195
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          197..199
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          201..205
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          208..212
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          217..231
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          260..264
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          269..271
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          278..280
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          283..287
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   HELIX           303..306
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   HELIX           311..354
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   HELIX           360..365
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          370..372
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          374..377
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   STRAND          380..382
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   HELIX           445..447
FT                   /evidence="ECO:0007829|PDB:5XEB"
FT   HELIX           449..464
FT                   /evidence="ECO:0007829|PDB:5XEB"
SQ   SEQUENCE   521 AA;  58676 MW;  34582A42BF306C18 CRC64;
     MVDSTIRLVA TIFLISLTQQ IEVCNKAQQQ GPYTLVDYQE KPLNISRIQI KVVKTSVATK
     GLNFHIGYRA VWRGYCYNGG SLDKNTGCYN DLIPKSPTES ELRTWSKSQK CCTGPDAVDA
     WGSDARICWA EWKMELCHTA KELKKYSNNN HFAYHTCNLS WRCGLKSTHI EVRLQASGGL
     VSMVAVMPNG TLIPIEGTRP TYWTEDSFAY LYDPAGTEKK TESTFLWCFK EHIRPTTELS
     GAVYDTHYLG GTYDKNPQFN YYCRDNGYYF ELPANRLVCL PTSCYKREGA IVNTMHPNTW
     KVSEKLHSAS QFDVNNVVHS LVYETEGLRL ALSQLDHRFA TLSRLFNRLT QSLAKIDDRL
     LGTLLGQDVS SKFISPTKFM LSPCLSTPEG DSNCHNHSIY RDGRWVHNSD PTQCFSLSKS
     QPVDLYSFKE LWLPQLLDVN VKGVVADEEG WSFVAQSKQA LIDTMTYTKN GGKGTSLEDV
     LGYPSGWING KLQGLLLNGA ISWVVVIGVV LVGVCLMRRV F