ID   AGN3_APLFA              Reviewed;          85 AA.
AC   P17681;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Abdominal ganglion neuropeptide R3-14;
DE   Contains:
DE     RecName: Full=Histidine-rich basic peptide;
DE              Short=HRBP;
DE   Contains:
DE     RecName: Full=Peptide I;
DE   Contains:
DE     RecName: Full=Peptide II;
OS   Aplysia fasciata (Mottled sea hare) (Aplysia brasiliana).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=144767;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-43.
RC   TISSUE=Abdominal ganglion;
RX   PubMed=2587425; DOI=10.1016/0196-9781(89)90125-3;
RA   Knock S.L., Nagle G.T., Lin C.Y., McAdoo D.J., Kurosky A.;
RT   "Aplysia brasiliana neurons R3-R14: primary structure of the myoactive
RT   histidine-rich basic peptide and its prohormone.";
RL   Peptides 10:859-867(1989).
CC   -!- FUNCTION: HRBP is a myoactive peptide that excites Aplysia heart and
CC       enhances gut motility in vitro.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neurons R3-R14. A cluster of 12 giant neurons
CC       located on the right side of the abdominal ganglion.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A44961; A44961.
DR   AlphaFoldDB; P17681; -.
DR   SMR; P17681; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..26
FT                   /note="Peptide I"
FT                   /evidence="ECO:0000269|PubMed:2587425"
FT                   /id="PRO_0000001785"
FT   PEPTIDE         29..40
FT                   /note="Peptide II"
FT                   /evidence="ECO:0000269|PubMed:2587425"
FT                   /id="PRO_0000001786"
FT   PEPTIDE         43..85
FT                   /note="Histidine-rich basic peptide"
FT                   /evidence="ECO:0000269|PubMed:2587425"
FT                   /id="PRO_0000001787"
FT   MOD_RES         43
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2587425"
SQ   SEQUENCE   85 AA;  9837 MW;  ADDD6329B2962D73 CRC64;
     EEVFDDTDVG DELTNALESV LTDLKDKRDA EEPSAFMTRL RRQVAQMHIW RAVNHDRHHS
     TGSGRHSRFL TRNRYRYGGG HLSDA