ID   AGN9_PAEDI              Reviewed;         439 AA.
AC   A0A411PQN9;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   03-AUG-2022, entry version 8.
DE   RecName: Full=Agnestins biosynthesis cluster transcriptional coactivator AgnL9 {ECO:0000303|PubMed:30746079};
DE   AltName: Full=Agnestins biosynthesis cluster protein L9 {ECO:0000303|PubMed:30746079};
GN   Name=AgnL9 {ECO:0000303|PubMed:30746079};
OS   Paecilomyces divaricatus (Penicillium divaricatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX   NCBI_TaxID=644132;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=K5013;
RX   PubMed=30746079; DOI=10.1039/c8sc03778g;
RA   Szwalbe A.J., Williams K., Song Z., de Mattos-Shipley K., Vincent J.L.,
RA   Bailey A.M., Willis C.L., Cox R.J., Simpson T.J.;
RT   "Characterisation of the biosynthetic pathway to agnestins A and B reveals
RT   the reductive route to chrysophanol in fungi.";
RL   Chem. Sci. 10:233-238(2019).
CC   -!- FUNCTION: Transcriptional coactivator; part of the gene cluster that
CC       mediates the biosynthesis of agnestins, dihydroxy-xanthone metabolites.
CC       {ECO:0000269|PubMed:30746079}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; MH898872; QBG38879.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A411PQN9; -.
DR   SMR; A0A411PQN9; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..439
FT                   /note="Agnestins biosynthesis cluster transcriptional
FT                   coactivator AgnL9"
FT                   /id="PRO_0000449021"
FT   DOMAIN          79..149
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DNA_BIND        109..128
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   439 AA;  47553 MW;  10D59F4EA0D3EF2A CRC64;
     MADFAQLEVY IGDLSTAITS LITQCQRNGH ATGSPSENLS RLFGLEAPTE AHRARESALV
     ILTKLQIMLA GPTDLLQQMT IQTQLLACIR WLGEFQVPAC IPLDGSALMK DVSELIDVPE
     NQLGRIVRMA ATCGFLREPE PGHITHSALS ASFVTNPSYL DAAMFLAETA APAALDMVAA
     TKQRLGSSEP ASQNVVFDQG FFSAANKTQL RRLQRQWQAY LRHGMAHLCD ITTDFLTCLE
     PLRMGNASIV EVGARSAERA MALVDQYPTL HFTVQLSPAS TLSSASKNGT AASKVRHPRI
     RVQHRVPGTP QPIQDAMVYI INFPVPEPGV SYNSPVAQIS AELRAHLAPL RMNRSATIVL
     TAPSLPERGN VAAVGVARIR DLSLLQLANE QEVEMSDLLS LLNGVGDGEG RLVLVNEMRS
     AGNHGAVALE VKYQSYTDR