AGNO1_BFPYV
ID AGNO1_BFPYV Reviewed; 176 AA.
AC A6QL29; A6QL30;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 23-FEB-2022, entry version 36.
DE RecName: Full=Avian agnoprotein 1a;
DE AltName: Full=Agno-1a;
OS Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; Gammapolyomavirus.
OX NCBI_TaxID=1891747;
OH NCBI_TaxID=9224; Psittacidae (parrots).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Li T., Kou Z., Fan Z., Chen S., Xiong K., Zhang Z.;
RT "The genome of budgerigar fledgling disease virus.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP ISOFORM AGNO-1B.
RX PubMed=7844527; DOI=10.1099/0022-1317-76-1-161;
RA Luo D., Muller H., Tang X.B., Hobom G.;
RT "Early and late pre-mRNA processing of budgerigar fledgling disease virus
RT 1: identification of viral RNA 5' and 3' ends and internal splice
RT junctions.";
RL J. Gen. Virol. 76:161-166(1995).
RN [3]
RP MUTAGENESIS OF SER-53; SER-93; THR-97; PRO-136; THR-137; 141-THR-THR-142
RP AND PRO-147.
RX PubMed=10644834; DOI=10.1099/0022-1317-81-2-359;
RA Liu Q., Hobom G.;
RT "Agnoprotein-1a of avian polyomavirus budgerigar fledgling disease virus:
RT identification of phosphorylation sites and functional importance in the
RT virus life-cycle.";
RL J. Gen. Virol. 81:359-367(2000).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH VP1.
RX PubMed=11257197; DOI=10.1099/0022-1317-82-4-909;
RA Johne R., Muller H.;
RT "Avian polyomavirus agnoprotein 1a is incorporated into the virus particle
RT as a fourth structural protein, VP4.";
RL J. Gen. Virol. 82:909-918(2001).
CC -!- SUBUNIT: Interacts with VP1. {ECO:0000269|PubMed:11257197}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:11257197}. Host
CC nucleus {ECO:0000269|PubMed:11257197}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing, Alternative initiation; Named isoforms=7;
CC Name=Agno-1a;
CC IsoId=A6QL29-1; Sequence=Displayed;
CC Name=Agno-1b;
CC IsoId=A6QL29-2; Sequence=VSP_036021;
CC Name=Agno-2b;
CC IsoId=P13893-1; Sequence=External;
CC Name=Agno-2a;
CC IsoId=P13893-2; Sequence=External;
CC Name=VP1;
CC IsoId=P13891-1; Sequence=External;
CC Name=VP2; Synonyms=Minor capsid protein VP2;
CC IsoId=P13892-1; Sequence=External;
CC Name=VP3; Synonyms=Minor capsid protein VP3;
CC IsoId=P13892-2; Sequence=External;
CC -!- MISCELLANEOUS: [Isoform Agno-1a]: Produced by alternative initiation of
CC the late mRNA.
CC -!- MISCELLANEOUS: [Isoform Agno-1b]: Produced by alternative splicing of
CC the late mRNA. {ECO:0000305}.
CC -!- CAUTION: Encoded by the same late mRNA leader region, but is very
CC different from primate polyomavirus agnoproteins. {ECO:0000305}.
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DR EMBL; AY672646; AAW52589.1; -; Genomic_DNA.
DR EMBL; AY672646; AAW52590.1; -; Genomic_DNA.
DR Proteomes; UP000144582; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Alternative initiation; Alternative splicing; Coiled coil; Host nucleus;
KW Host-virus interaction; Phosphoprotein; Virion.
FT CHAIN 1..176
FT /note="Avian agnoprotein 1a"
FT /id="PRO_0000356261"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..119
FT /evidence="ECO:0000255"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 69..132
FT /note="Missing (in isoform Agno-1b)"
FT /evidence="ECO:0000305"
FT /id="VSP_036021"
FT MUTAGEN 53
FT /note="S->A: 80% loss of viral structural genes VP1, VP2
FT and VP3 expression."
FT /evidence="ECO:0000269|PubMed:10644834"
FT MUTAGEN 93
FT /note="S->L: 80% loss of viral structural genes VP1, VP2
FT and VP3 expression."
FT /evidence="ECO:0000269|PubMed:10644834"
FT MUTAGEN 97
FT /note="T->A: Complete loss of VP1, VP2 and VP3 expression."
FT /evidence="ECO:0000269|PubMed:10644834"
FT MUTAGEN 136
FT /note="P->A: Complete loss of VP1, VP2 and VP3 expression."
FT /evidence="ECO:0000269|PubMed:10644834"
FT MUTAGEN 137
FT /note="T->A: Complete loss of VP1, VP2 and VP3 expression."
FT /evidence="ECO:0000269|PubMed:10644834"
FT MUTAGEN 141..142
FT /note="TT->GA: Complete loss of VP1, VP2 and VP3
FT expression."
FT /evidence="ECO:0000269|PubMed:10644834"
FT MUTAGEN 147
FT /note="P->A: 80% loss of viral structural genes VP1, VP2
FT and VP3 expression."
FT /evidence="ECO:0000269|PubMed:10644834"
SQ SEQUENCE 176 AA; 18606 MW; B26B093690C7117A CRC64;
MSTPARDPNT AGTAALSPFS TPNHELRAPG PGEAHSPFTP TAAPGSQPAG SLSDPEDGPD
PTFNFYIQGH RRRPYDRQNR FGKLESEIRE TKSQLETLRQ ELKHLQADVD DLKETVYAAG
TSTASTSVPP SQPNSPTPTA TTPEASPAAP TTESTETTGP SVATNATEPS ESRPAR
