ID   ENV_NPVLD               Reviewed;         676 AA.
AC   Q9YMJ7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Envelope fusion protein;
DE   Flags: Precursor;
GN   OrderedLocusNames=LdOrf-130;
OS   Lymantria dispar multicapsid nuclear polyhedrosis virus (LdMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=10449;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9887315; DOI=10.1006/viro.1998.9469;
RA   Kuzio J., Pearson M.N., Harwood S.H., Funk C.J., Evans J.T., Slavicek J.M.,
RA   Rohrmann G.F.;
RT   "Sequence and analysis of the genome of a baculovirus pathogenic for
RT   Lymantria dispar.";
RL   Virology 253:17-34(1999).
RN   [2]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=10846096; DOI=10.1128/jvi.74.13.6126-6131.2000;
RA   Pearson M.N., Groten C., Rohrmann G.F.;
RT   "Identification of the lymantria dispar nucleopolyhedrovirus envelope
RT   fusion protein provides evidence for a phylogenetic division of the
RT   Baculoviridae.";
RL   J. Virol. 74:6126-6131(2000).
CC   -!- FUNCTION: Envelope glycoprotein which mediates the fusion of viral and
CC       host endosomal membranes leading to virus entry into the host cell.
CC       {ECO:0000269|PubMed:10846096}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- PTM: N-glycosylated.
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DR   EMBL; AF081810; AAC70316.1; -; Genomic_DNA.
DR   PIR; T30480; T30480.
DR   RefSeq; NP_047767.1; NC_001973.1.
DR   GeneID; 1488571; -.
DR   KEGG; vg:1488571; -.
DR   Proteomes; UP000203997; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR022048; Envelope_fusion-like.
DR   Pfam; PF12259; Baculo_F; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Fusion of virus membrane with host endosomal membrane;
KW   Fusion of virus membrane with host membrane; Glycoprotein;
KW   Host cell membrane; Host membrane; Membrane; Signal; Transmembrane;
KW   Transmembrane helix; Viral envelope protein;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..676
FT                   /note="Envelope fusion protein"
FT                   /id="PRO_0000406911"
FT   TRANSMEM        577..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          169..215
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        266
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        469
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        505
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        548
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        628
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   676 AA;  76738 MW;  759564C2614620EE CRC64;
     MSPLALIVLL AWHATAFKST DTIEVIPLPH TSGFYYQPIN RMQFVEDVWH FIIEVDHGVI
     FQELDELYRD TLHLLNHTRS SKFVSANCTT NAIIESEINT YILKRILYLV QQHNTIDDKI
     KANAEGDAPD SRWELNTKDP LAPRRKRGVL NFVGTVDKFL FGVMDSNDAR ELHDLAKTSN
     ALNEQIKEVT DELVNIAKFE EHKQCLERQR DDLCGYATAK MALITEQLTQ LDLLYTNLDR
     AVDDALDNRI NSLIMTPQRL YEEMTNVTVH VPTKLTWPVP LKKTNMHDLI NDKIVKTHVF
     KLERRKLIFI LEVPLIDDQN YDVYQVIPIP LCGGDGKCAV IVPDSKYLGV STNKRNYVRL
     EDDAPKACKM TSKNLLCFKP KVVHVSSEAT LCDIKILLHY ENSYENVQRD CDVRVGKFDP
     EIFHLISDYN NWLYVLQRDT ELTMDCADAS SASNVIRIAA GTGIIRGRNV TRSCNLMTKS
     KQLALHQLKN SLFSVSAVPL STSFNLSAAL GDLDRLEIES MKNNADLDHK HLQGATQRLI
     DLRKRMNNNS VFHGAELEGE ASDGWFCWLV GWLNIKCATA EAVVACVVLF LVALLLFRIY
     RFCCPGTCSA MFSCCRFDAL SSVPRRRNKT KSSVIRVNSQ LQYLDGGGGG EKSHEETPMV
     MFNNRARDPN VVFKNI