ENV_THOGV
ID ENV_THOGV Reviewed; 512 AA.
AC P28977;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 02-JUN-2021, entry version 72.
DE RecName: Full=Envelope glycoprotein;
DE AltName: Full=Surface glycoprotein 75;
DE Flags: Precursor;
GN OrderedLocusNames=Segment 4;
OS Thogoto virus (isolate SiAr 126) (Tho).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Thogotovirus.
OX NCBI_TaxID=126796;
OH NCBI_TaxID=34610; Amblyomma variegatum (Tropical bont tick).
OH NCBI_TaxID=10144; Cavia cutleri (Guinea pig).
OH NCBI_TaxID=210652; Mungos mungo (Banded mongoose).
OH NCBI_TaxID=34631; Rhipicephalus appendiculatus (Brown ear tick).
OH NCBI_TaxID=6941; Rhipicephalus microplus (Cattle tick) (Boophilus microplus).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1733105; DOI=10.1016/0042-6822(92)90030-s;
RA Morse M.A., Marriott A.C., Nuttall P.A.;
RT "The glycoprotein of Thogoto virus (a tick-borne orthomyxo-like virus) is
RT related to the baculovirus glycoprotein GP64.";
RL Virology 186:640-646(1992).
CC -!- FUNCTION: Attaches the virus to host cellular receptor and later
CC induces fusion of virion with host membrane. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}.
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DR EMBL; M77280; AAA47918.1; -; Genomic_RNA.
DR PIR; A40821; VGIVTH.
DR RefSeq; YP_145808.1; NC_006506.1.
DR PDB; 5XEA; X-ray; 2.09 A; A/B/C=18-483.
DR PDBsum; 5XEA; -.
DR SMR; P28977; -.
DR TCDB; 1.G.15.1.4; the autographa californica nuclear polyhedrosis virus major envelope glycoprotein gp64 (gp64) family.
DR GeneID; 5075737; -.
DR KEGG; vg:5075737; -.
DR Proteomes; UP000008973; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR InterPro; IPR004955; Baculovirus_Gp64.
DR Pfam; PF03273; Baculo_gp64; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Virion.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..512
FT /note="Envelope glycoprotein"
FT /id="PRO_0000039175"
FT TRANSMEM 479..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 263
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 416
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT STRAND 25..30
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 41..53
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 57..74
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 82..89
FT /evidence="ECO:0007829|PDB:5XEA"
FT HELIX 94..103
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 106..108
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 112..116
FT /evidence="ECO:0007829|PDB:5XEA"
FT HELIX 117..123
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 131..135
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 150..166
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 169..173
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 176..182
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 188..191
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 197..201
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 204..209
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 214..227
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 238..243
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 246..250
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 252..257
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 260..264
FT /evidence="ECO:0007829|PDB:5XEA"
FT HELIX 285..287
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 294..296
FT /evidence="ECO:0007829|PDB:5XEA"
FT HELIX 299..344
FT /evidence="ECO:0007829|PDB:5XEA"
FT HELIX 348..352
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 357..365
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 367..371
FT /evidence="ECO:0007829|PDB:5XEA"
FT STRAND 410..412
FT /evidence="ECO:0007829|PDB:5XEA"
FT HELIX 434..436
FT /evidence="ECO:0007829|PDB:5XEA"
FT HELIX 438..454
FT /evidence="ECO:0007829|PDB:5XEA"
SQ SEQUENCE 512 AA; 57550 MW; 0398FC36284A0DF1 CRC64;
MFLQTALLLL SLGVAEPDCN TKTATGPYIL DRYKPKPVTV SKKLYSATRY TTSAQNELLT
AGYRTAWVAY CYNGGLVDSN TGCNARLLHY PPSRDELLLW GSSHQCSYGD ICHDCWGSDS
YACLGQLDPA KHWAPRKELV RRDANWKFAY HMCNIDWRCG VTTSPVFFNL QWVKNEVKVS
TLLPNGSTVE HSAGEPLFWT EKDFSYLVKD NFEIQREEVK ISCFVDPDYW VGERKTKKAF
CQDGTNFFEV TSHQFCHQYA CYNFSKDELL EAVYKERAHE KSKDLPFGNK SWTVVTASID
DLHALSAAQA FELEGLRASF AELDSRFRQL SEILDTVISS IAKIDERLIG RLIKAPVSSR
FISEDKFLLH QCVDSVANNT NCVGDSAYVD GRWTHVGDNH PCTTVVDEPI GIDIYNFSAL
WYPSAAEVDF RGTVQSEDGW SFVVKSKDAL IQTMMYTKNG GKGTSLTDLL DYPSGWLKGQ
LGGLLYGNIG VYLLIAFAFV LLIRLIKSAG LC
