ID   ENY2A_SALSA             Reviewed;          95 AA.
AC   B5XC71; B5X8H8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Transcription and mRNA export factor ENY2-1 {ECO:0000255|HAMAP-Rule:MF_03046};
DE   AltName: Full=Enhancer of yellow 2 transcription factor homolog A {ECO:0000255|HAMAP-Rule:MF_03046};
GN   Name=eny2-1;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC       association with both the TREX-2 and the SAGA complexes. The
CC       transcription regulatory histone acetylation (HAT) complex SAGA is a
CC       multiprotein complex that activates transcription by remodeling
CC       chromatin and mediating histone acetylation and deubiquitination.
CC       Within the SAGA complex, participates in a subcomplex that specifically
CC       deubiquitinates histones. The SAGA complex is recruited to specific
CC       gene promoters by activators, where it is required for transcription.
CC       The TREX-2 complex functions in docking export-competent
CC       ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC       nuclear pore complex (nuclear basket). TREX-2 participates in mRNA
CC       export and accurate chromatin positioning in the nucleus by tethering
CC       genes to the nuclear periphery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC       complex (transcription and export complex 2). Component of the SAGA
CC       transcription coactivator-HAT complex. Within the SAGA complex,
CC       participates in a subcomplex of SAGA called the DUB module
CC       (deubiquitination module) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
CC   -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
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DR   EMBL; BT047347; ACI67148.1; -; mRNA.
DR   EMBL; BT048640; ACI68441.1; -; mRNA.
DR   RefSeq; XP_014023807.1; XM_014168332.1.
DR   AlphaFoldDB; B5XC71; -.
DR   SMR; B5XC71; -.
DR   GeneID; 106583768; -.
DR   KEGG; sasa:106583768; -.
DR   OrthoDB; 1538551at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa02.
DR   GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR   GO; GO:0000124; C:SAGA complex; ISS:UniProtKB.
DR   GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016578; P:histone deubiquitination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.246.140; -; 1.
DR   HAMAP; MF_03046; ENY2_Sus1; 1.
DR   InterPro; IPR018783; TF_ENY2.
DR   InterPro; IPR038212; TF_EnY2_sf.
DR   PANTHER; PTHR12514; PTHR12514; 1.
DR   Pfam; PF10163; EnY2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; mRNA transport; Nucleus; Protein transport;
KW   Reference proteome; Transcription; Transcription regulation; Translocation;
KW   Transport.
FT   CHAIN           1..95
FT                   /note="Transcription and mRNA export factor ENY2-1"
FT                   /id="PRO_0000367547"
FT   CONFLICT        57
FT                   /note="A -> V (in Ref. 1; ACI67148)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="R -> K (in Ref. 1; ACI67148)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   95 AA;  10940 MW;  68D0CD635797993F CRC64;
     MSKDSKMRAT INQKLTEMGE RERLKELLRA KLTECGWRDQ LKALCKDVIK EKGLEHATVE
     DLVVEITPKG RVLVPDSVKR ELLQRIRAFL AQHAT