ENY2B_DROME
ID ENY2B_DROME Reviewed; 95 AA.
AC Q9VI60;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Enhancer of yellow 2b transcription factor;
DE AltName: Full=Testis-specific e(y)2 paralog;
GN Name=e(y)2b; ORFNames=CG14612;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND INTERACTION WITH E(Y)1.
RX PubMed=11438676; DOI=10.1128/mcb.21.15.5223-5231.2001;
RA Georgieva S., Nabirochkina E., Dilworth F.J., Eickhoff H., Becker P.,
RA Tora L., Georgiev P., Soldatov A.;
RT "The novel transcription factor e(y)2 interacts with TAF(II)40 and
RT potentiates transcription activation on chromatin templates.";
RL Mol. Cell. Biol. 21:5223-5231(2001).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16314324; DOI=10.1093/nar/gki969;
RA Krasnov A.N., Kurshakova M.M., Ramensky V.E., Mardanov P.V.,
RA Nabirochkina E.N., Georgieva S.G.;
RT "A retrocopy of a gene can functionally displace the source gene in
RT evolution.";
RL Nucleic Acids Res. 33:6654-6661(2005).
CC -!- FUNCTION: Testis-specific paralog of the ubiquitously expressed
CC transcription and mRNA export factor e(y)2. Cannot functionally replace
CC e(y)2. {ECO:0000269|PubMed:11438676, ECO:0000269|PubMed:16314324}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in testis.
CC {ECO:0000269|PubMed:11438676, ECO:0000269|PubMed:16314324}.
CC -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54066.1; -; Genomic_DNA.
DR RefSeq; NP_001287204.1; NM_001300275.1.
DR RefSeq; NP_652310.1; NM_144053.2.
DR AlphaFoldDB; Q9VI60; -.
DR SMR; Q9VI60; -.
DR BioGRID; 72562; 14.
DR IntAct; Q9VI60; 7.
DR STRING; 7227.FBpp0081083; -.
DR PaxDb; Q9VI60; -.
DR DNASU; 50143; -.
DR EnsemblMetazoa; FBtr0081562; FBpp0081083; FBgn0040670.
DR EnsemblMetazoa; FBtr0344948; FBpp0311218; FBgn0040670.
DR GeneID; 50143; -.
DR KEGG; dme:Dmel_CG14612; -.
DR UCSC; CG14612-RA; d. melanogaster.
DR CTD; 50143; -.
DR FlyBase; FBgn0040670; e(y)2b.
DR VEuPathDB; VectorBase:FBgn0040670; -.
DR eggNOG; KOG4479; Eukaryota.
DR HOGENOM; CLU_134052_1_3_1; -.
DR InParanoid; Q9VI60; -.
DR OMA; CGWRKDI; -.
DR OrthoDB; 1538551at2759; -.
DR PhylomeDB; Q9VI60; -.
DR SignaLink; Q9VI60; -.
DR BioGRID-ORCS; 50143; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 50143; -.
DR PRO; PR:Q9VI60; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0040670; Expressed in testis and 12 other tissues.
DR ExpressionAtlas; Q9VI60; baseline and differential.
DR Genevisible; Q9VI60; DM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0071819; C:DUBm complex; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; ISS:FlyBase.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0016578; P:histone deubiquitination; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.246.140; -; 1.
DR HAMAP; MF_03046; ENY2_Sus1; 1.
DR InterPro; IPR018783; TF_ENY2.
DR InterPro; IPR038212; TF_EnY2_sf.
DR PANTHER; PTHR12514; PTHR12514; 1.
DR Pfam; PF10163; EnY2; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..95
FT /note="Enhancer of yellow 2b transcription factor"
FT /id="PRO_0000423833"
SQ SEQUENCE 95 AA; 10829 MW; E8396BEC20661912 CRC64;
MTINKETGTD PDPGYKPTLR SQDKAALKEL LHTRLVECGW HKDIKEMIRN IIMERGVDNI
NRDQLAAQIV PQARALVPEV VKNEMMLRVH AALDK
