ENY2_BOVIN
ID ENY2_BOVIN Reviewed; 101 AA.
AC Q3ZBJ0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046};
DE AltName: Full=Enhancer of yellow 2 transcription factor homolog {ECO:0000255|HAMAP-Rule:MF_03046};
GN Name=ENY2 {ECO:0000255|HAMAP-Rule:MF_03046};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC association with both the TREX-2 and the SAGA complexes. The
CC transcription regulatory histone acetylation (HAT) complex SAGA is a
CC multiprotein complex that activates transcription by remodeling
CC chromatin and mediating histone acetylation and deubiquitination.
CC Within the SAGA complex, participates in a subcomplex that specifically
CC deubiquitinates both histones H2A and H2B. The SAGA complex is
CC recruited to specific gene promoters by activators such as MYC, where
CC it is required for transcription. Required for nuclear receptor-
CC mediated transactivation. As a component of the TREX-2 complex,
CC involved in the export of mRNAs to the cytoplasm through the nuclear
CC pores (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9NPA8}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC complex (transcription and export complex 2), composed of at least
CC ENY2, the isoform GANP of the MCM3AP gene, PCID2, SEM1, and either
CC centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2
CC complex also associates with ALYREF/ALY and with the nucleoporin NUP153
CC (By similarity). Component of some SAGA transcription coactivator-HAT
CC complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H,
CC TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3,
CC and USP22 form an additional subcomplex of SAGA called the DUB module
CC (deubiquitination module). Interacts with the RNA polymerase II subunit
CC POLR2A (By similarity). Interacts with ATXN7L3B (By similarity).
CC {ECO:0000250|UniProtKB:Q9NPA8, ECO:0000255|HAMAP-Rule:MF_03046}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC Rule:MF_03046}.
CC -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03046}.
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DR EMBL; BC103269; AAI03270.1; -; mRNA.
DR RefSeq; NP_001029919.1; NM_001034747.2.
DR AlphaFoldDB; Q3ZBJ0; -.
DR SMR; Q3ZBJ0; -.
DR STRING; 9913.ENSBTAP00000009712; -.
DR PaxDb; Q3ZBJ0; -.
DR PeptideAtlas; Q3ZBJ0; -.
DR PRIDE; Q3ZBJ0; -.
DR Ensembl; ENSBTAT00000009712; ENSBTAP00000009712; ENSBTAG00000007387.
DR GeneID; 614069; -.
DR KEGG; bta:614069; -.
DR CTD; 56943; -.
DR VEuPathDB; HostDB:ENSBTAG00000007387; -.
DR VGNC; VGNC:28514; ENY2.
DR eggNOG; KOG4479; Eukaryota.
DR GeneTree; ENSGT00390000011748; -.
DR HOGENOM; CLU_134052_1_1_1; -.
DR InParanoid; Q3ZBJ0; -.
DR OMA; RLMCRNI; -.
DR OrthoDB; 1538551at2759; -.
DR TreeFam; TF326556; -.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000007387; Expressed in oocyte and 105 other tissues.
DR GO; GO:0071819; C:DUBm complex; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0044615; C:nuclear pore nuclear basket; ISS:UniProtKB.
DR GO; GO:0000124; C:SAGA complex; ISS:UniProtKB.
DR GO; GO:0070390; C:transcription export complex 2; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0016578; P:histone deubiquitination; IBA:GO_Central.
DR GO; GO:0043966; P:histone H3 acetylation; IEA:Ensembl.
DR GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; IEA:Ensembl.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.246.140; -; 1.
DR HAMAP; MF_03046; ENY2_Sus1; 1.
DR InterPro; IPR018783; TF_ENY2.
DR InterPro; IPR038212; TF_EnY2_sf.
DR PANTHER; PTHR12514; PTHR12514; 1.
DR Pfam; PF10163; EnY2; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; Isopeptide bond; mRNA transport; Nucleus;
KW Protein transport; Reference proteome; Transcription;
KW Transcription regulation; Translocation; Transport; Ubl conjugation.
FT CHAIN 1..101
FT /note="Transcription and mRNA export factor ENY2"
FT /id="PRO_0000314129"
FT CROSSLNK 74
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NPA8"
SQ SEQUENCE 101 AA; 11529 MW; A0617024C59AABFB CRC64;
MVVSKMNKDA QMRAAINQKL IETGERERLK ELLRAKLIEC GWKDQLKAHC KEVIKEKGLE
HVTVDDLVAE ITPKGRALVP DSVKKELLQR IRTFLAQHAS L
