ID   ENY2_CULQU              Reviewed;          92 AA.
AC   B0WG73;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Enhancer of yellow 2 transcription factor {ECO:0000255|HAMAP-Rule:MF_03046};
GN   Name=e(y)2 {ECO:0000255|HAMAP-Rule:MF_03046}; ORFNames=CPIJ005882;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC       association with both the TREX-2 and the SAGA complexes. The
CC       transcription regulatory histone acetylation (HAT) complex SAGA is a
CC       multiprotein complex that activates transcription by remodeling
CC       chromatin and mediating histone acetylation and deubiquitination.
CC       Within the SAGA complex, participates in a subcomplex that specifically
CC       deubiquitinates histones. The SAGA complex is recruited to specific
CC       gene promoters by activators, where it is required for transcription.
CC       The TREX-2 complex functions in docking export-competent
CC       ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC       nuclear pore complex (nuclear basket). TREX-2 participates in mRNA
CC       export and accurate chromatin positioning in the nucleus by tethering
CC       genes to the nuclear periphery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC       complex (transcription and export complex 2). Component of the SAGA
CC       transcription coactivator-HAT complex. Within the SAGA complex,
CC       participates in a subcomplex of SAGA called the DUB module
CC       (deubiquitination module) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
CC   -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
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DR   EMBL; DS231923; EDS26769.1; -; Genomic_DNA.
DR   RefSeq; XP_001847707.1; XM_001847655.1.
DR   AlphaFoldDB; B0WG73; -.
DR   SMR; B0WG73; -.
DR   STRING; 7176.CPIJ005882-PA; -.
DR   GeneID; 6037833; -.
DR   KEGG; cqu:CpipJ_CPIJ005882; -.
DR   VEuPathDB; VectorBase:CPIJ005882; -.
DR   VEuPathDB; VectorBase:CQUJHB008965; -.
DR   eggNOG; KOG4479; Eukaryota.
DR   HOGENOM; CLU_134052_1_1_1; -.
DR   InParanoid; B0WG73; -.
DR   OMA; RLMCRNI; -.
DR   OrthoDB; 1538551at2759; -.
DR   PhylomeDB; B0WG73; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR   GO; GO:0000124; C:SAGA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016578; P:histone deubiquitination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.246.140; -; 1.
DR   HAMAP; MF_03046; ENY2_Sus1; 1.
DR   InterPro; IPR018783; TF_ENY2.
DR   InterPro; IPR038212; TF_EnY2_sf.
DR   PANTHER; PTHR12514; PTHR12514; 1.
DR   Pfam; PF10163; EnY2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; mRNA transport; Nucleus; Protein transport;
KW   Reference proteome; Transcription; Transcription regulation; Translocation;
KW   Transport.
FT   CHAIN           1..92
FT                   /note="Enhancer of yellow 2 transcription factor"
FT                   /id="PRO_0000367552"
SQ   SEQUENCE   92 AA;  10462 MW;  8331F92D06D4CE70 CRC64;
     MTFTKSVDQT TILQGDRSKL KDLLRVRLNA CGWNDQVRLL CRETIKDQDT VNCDALVQQV
     TPKARALIPD TVKKELLQKI KAILIQQEGI DI