ID   ENY2_DANRE              Reviewed;          95 AA.
AC   Q6DH42;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046};
DE   AltName: Full=Enhancer of yellow 2 transcription factor homolog {ECO:0000255|HAMAP-Rule:MF_03046};
GN   Name=eny2; ORFNames=zgc:92656;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC       association with both the TREX-2 and the SAGA complexes. The
CC       transcription regulatory histone acetylation (HAT) complex SAGA is a
CC       multiprotein complex that activates transcription by remodeling
CC       chromatin and mediating histone acetylation and deubiquitination.
CC       Within the SAGA complex, participates in a subcomplex that specifically
CC       deubiquitinates histones. The SAGA complex is recruited to specific
CC       gene promoters by activators, where it is required for transcription.
CC       The TREX-2 complex functions in docking export-competent
CC       ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC       nuclear pore complex (nuclear basket). TREX-2 participates in mRNA
CC       export and accurate chromatin positioning in the nucleus by tethering
CC       genes to the nuclear periphery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC       complex (transcription and export complex 2). Component of the SAGA
CC       transcription coactivator-HAT complex. Within the SAGA complex,
CC       participates in a subcomplex of SAGA called the DUB module
CC       (deubiquitination module) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
CC   -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
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DR   EMBL; BC076140; AAH76140.1; -; mRNA.
DR   RefSeq; NP_001002427.1; NM_001002427.2.
DR   AlphaFoldDB; Q6DH42; -.
DR   SMR; Q6DH42; -.
DR   STRING; 7955.ENSDARP00000115433; -.
DR   PaxDb; Q6DH42; -.
DR   Ensembl; ENSDART00000102482; ENSDARP00000093259; ENSDARG00000070046.
DR   Ensembl; ENSDART00000136215; ENSDARP00000115433; ENSDARG00000070046.
DR   GeneID; 436700; -.
DR   KEGG; dre:436700; -.
DR   CTD; 56943; -.
DR   ZFIN; ZDB-GENE-040718-124; eny2.
DR   eggNOG; KOG4479; Eukaryota.
DR   GeneTree; ENSGT00390000011748; -.
DR   HOGENOM; CLU_134052_1_1_1; -.
DR   InParanoid; Q6DH42; -.
DR   OMA; RLMCRNI; -.
DR   OrthoDB; 1538551at2759; -.
DR   PhylomeDB; Q6DH42; -.
DR   TreeFam; TF326556; -.
DR   PRO; PR:Q6DH42; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000070046; Expressed in mature ovarian follicle and 28 other tissues.
DR   GO; GO:0071819; C:DUBm complex; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR   GO; GO:0000124; C:SAGA complex; ISS:UniProtKB.
DR   GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016578; P:histone deubiquitination; IBA:GO_Central.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.246.140; -; 1.
DR   HAMAP; MF_03046; ENY2_Sus1; 1.
DR   InterPro; IPR018783; TF_ENY2.
DR   InterPro; IPR038212; TF_EnY2_sf.
DR   PANTHER; PTHR12514; PTHR12514; 1.
DR   Pfam; PF10163; EnY2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; mRNA transport; Nucleus; Protein transport;
KW   Reference proteome; Transcription; Transcription regulation; Translocation;
KW   Transport.
FT   CHAIN           1..95
FT                   /note="Transcription and mRNA export factor ENY2"
FT                   /id="PRO_0000314132"
SQ   SEQUENCE   95 AA;  10813 MW;  18B9D63E3C197819 CRC64;
     MSKESQMRAA INQKLIEMGE RERLKELLRA KLIECGWRDQ LKALCKEVIK EKGIENVTVE
     DLVAGVTPKG RALVPDSVKK ELLQRIRAFL AQHST