ID   ENY2_DICDI              Reviewed;         123 AA.
AC   Q54HB4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046};
DE   AltName: Full=Enhancer of yellow 2 transcription factor homolog {ECO:0000255|HAMAP-Rule:MF_03046};
GN   Name=eny2; ORFNames=DDB_G0289573;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC       association with both the TREX-2 and the SAGA complexes. The
CC       transcription regulatory histone acetylation (HAT) complex SAGA is a
CC       multiprotein complex that activates transcription by remodeling
CC       chromatin and mediating histone acetylation and deubiquitination.
CC       Within the SAGA complex, participates in a subcomplex that specifically
CC       deubiquitinates histones. The SAGA complex is recruited to specific
CC       gene promoters by activators, where it is required for transcription.
CC       The TREX-2 complex functions in docking export-competent
CC       ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC       nuclear pore complex (nuclear basket). TREX-2 participates in mRNA
CC       export and accurate chromatin positioning in the nucleus by tethering
CC       genes to the nuclear periphery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC       complex (transcription and export complex 2). Component of the SAGA
CC       transcription coactivator-HAT complex. Within the SAGA complex,
CC       participates in a subcomplex of SAGA called the DUB module
CC       (deubiquitination module) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
CC   -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
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DR   EMBL; AAFI02000145; EAL62653.1; -; Genomic_DNA.
DR   RefSeq; XP_636159.1; XM_631067.1.
DR   AlphaFoldDB; Q54HB4; -.
DR   SMR; Q54HB4; -.
DR   STRING; 44689.DDB0266473; -.
DR   PaxDb; Q54HB4; -.
DR   EnsemblProtists; EAL62653; EAL62653; DDB_G0289573.
DR   GeneID; 8627213; -.
DR   KEGG; ddi:DDB_G0289573; -.
DR   dictyBase; DDB_G0289573; -.
DR   eggNOG; KOG4479; Eukaryota.
DR   HOGENOM; CLU_134052_2_0_1; -.
DR   InParanoid; Q54HB4; -.
DR   OMA; RLMCRNI; -.
DR   PhylomeDB; Q54HB4; -.
DR   PRO; PR:Q54HB4; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0071819; C:DUBm complex; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR   GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR   GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016578; P:histone deubiquitination; IBA:GO_Central.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.246.140; -; 1.
DR   HAMAP; MF_03046; ENY2_Sus1; 1.
DR   InterPro; IPR018783; TF_ENY2.
DR   InterPro; IPR038212; TF_EnY2_sf.
DR   PANTHER; PTHR12514; PTHR12514; 1.
DR   Pfam; PF10163; EnY2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; mRNA transport; Nucleus; Protein transport;
KW   Reference proteome; Transcription; Transcription regulation; Translocation;
KW   Transport.
FT   CHAIN           1..123
FT                   /note="Transcription and mRNA export factor ENY2"
FT                   /id="PRO_0000327964"
SQ   SEQUENCE   123 AA;  14234 MW;  B79FBD4E691D9480 CRC64;
     MASTTTTILP KDHIKLRSTI HQKLIESGEK ERLKVLLKSK LVEGGWRDEV KIACREYIKN
     NQNENFKIED LIALITPIAK KKVPPQVKAD LIKRIRKFLG PNIQNHHHHH IHIQSNTPNS
     PHH