ID   ENY2_DROPS              Reviewed;         100 AA.
AC   Q29IN4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Enhancer of yellow 2 transcription factor {ECO:0000255|HAMAP-Rule:MF_03046};
GN   Name=e(y)2 {ECO:0000255|HAMAP-Rule:MF_03046}; ORFNames=GA13559;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC       association with both the AMEX and the SAGA complexes. The SAGA complex
CC       is a multiprotein complex that activates transcription by remodeling
CC       chromatin and mediating histone acetylation and deubiquitination.
CC       Within the SAGA complex, participates in a subcomplex that specifically
CC       deubiquitinates histone H2B. The SAGA complex is recruited to specific
CC       gene promoters by activators, where it is required for transcription.
CC       Required for nuclear receptor-mediated transactivation. Involved in
CC       transcription elongation by recruiting the THO complex onto nascent
CC       mRNA. The AMEX complex functions in docking export-competent
CC       ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC       nuclear pore complex (nuclear basket). AMEX participates in mRNA export
CC       and accurate chromatin positioning in the nucleus by tethering genes to
CC       the nuclear periphery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated AMEX
CC       complex (anchoring and mRNA export complex), composed of at least e(y)2
CC       and xmas-2. Component of the SAGA transcription coactivator-HAT
CC       complexes, at least composed of Ada2b, e(y)2, Pcaf/Gcn5, Taf10 and
CC       Nipped-A/Trrap. Within the SAGA complex, e(y)2, Sgf11, and not/nonstop
CC       form an additional subcomplex of SAGA called the DUB module
CC       (deubiquitination module). Component of the THO complex, composed of at
CC       least e(y)2, HPR1, THO2, THOC5, THOC6 and THOC7. Interacts with e(y)1.
CC       Interacts with su(Hw) (via zinc fingers). Interacts with xmas-2;
CC       required for localization to the nuclear periphery. Interacts with the
CC       nuclear pore complex (NPC). {ECO:0000255|HAMAP-Rule:MF_03046}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03046}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03046}.
CC   -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
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DR   EMBL; CH379063; EAL32620.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q29IN4; -.
DR   SMR; Q29IN4; -.
DR   STRING; 7237.FBpp0272768; -.
DR   eggNOG; KOG4479; Eukaryota.
DR   HOGENOM; CLU_134052_1_2_1; -.
DR   InParanoid; Q29IN4; -.
DR   OMA; RLMCRNI; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR   GO; GO:0000124; C:SAGA complex; ISS:UniProtKB.
DR   GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR   GO; GO:0043035; F:chromatin insulator sequence binding; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016578; P:histone deubiquitination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.246.140; -; 1.
DR   HAMAP; MF_03046; ENY2_Sus1; 1.
DR   InterPro; IPR018783; TF_ENY2.
DR   InterPro; IPR038212; TF_EnY2_sf.
DR   PANTHER; PTHR12514; PTHR12514; 1.
DR   Pfam; PF10163; EnY2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Transcription;
KW   Transcription regulation; Translocation; Transport.
FT   CHAIN           1..100
FT                   /note="Enhancer of yellow 2 transcription factor"
FT                   /id="PRO_0000367558"
SQ   SEQUENCE   100 AA;  11387 MW;  645BC8E238215B07 CRC64;
     MTIFNAVDKF TMMSGDRVKI KDLLSSRLTE CGWRDEVRLL CRSILQEKGA ISSFTVEQLV
     TEVTPRARSL VPDAVKKELL IKIRTIFDEN EADDIDPEEA