ENY2_DROWI
ID ENY2_DROWI Reviewed; 119 AA.
AC B4N1G8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Enhancer of yellow 2 transcription factor {ECO:0000255|HAMAP-Rule:MF_03046};
GN Name=e(y)2 {ECO:0000255|HAMAP-Rule:MF_03046}; ORFNames=GK16303;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC association with both the AMEX and the SAGA complexes. The SAGA complex
CC is a multiprotein complex that activates transcription by remodeling
CC chromatin and mediating histone acetylation and deubiquitination.
CC Within the SAGA complex, participates in a subcomplex that specifically
CC deubiquitinates histone H2B. The SAGA complex is recruited to specific
CC gene promoters by activators, where it is required for transcription.
CC Required for nuclear receptor-mediated transactivation. Involved in
CC transcription elongation by recruiting the THO complex onto nascent
CC mRNA. The AMEX complex functions in docking export-competent
CC ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC nuclear pore complex (nuclear basket). AMEX participates in mRNA export
CC and accurate chromatin positioning in the nucleus by tethering genes to
CC the nuclear periphery (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated AMEX
CC complex (anchoring and mRNA export complex), composed of at least e(y)2
CC and xmas-2. Component of the SAGA transcription coactivator-HAT
CC complexes, at least composed of Ada2b, e(y)2, Pcaf/Gcn5, Taf10 and
CC Nipped-A/Trrap. Within the SAGA complex, e(y)2, Sgf11, and not/nonstop
CC form an additional subcomplex of SAGA called the DUB module
CC (deubiquitination module). Component of the THO complex, composed of at
CC least e(y)2, HPR1, THO2, THOC5, THOC6 and THOC7. Interacts with e(y)1.
CC Interacts with su(Hw) (via zinc fingers). Interacts with xmas-2;
CC required for localization to the nuclear periphery. Interacts with the
CC nuclear pore complex (NPC). {ECO:0000255|HAMAP-Rule:MF_03046}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC Rule:MF_03046}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03046}.
CC -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03046}.
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DR EMBL; CH963925; EDW78207.1; -; Genomic_DNA.
DR RefSeq; XP_002067221.2; XM_002067185.2.
DR AlphaFoldDB; B4N1G8; -.
DR SMR; B4N1G8; -.
DR STRING; 7260.FBpp0245446; -.
DR EnsemblMetazoa; FBtr0246954; FBpp0245446; FBgn0218305.
DR GeneID; 6644730; -.
DR KEGG; dwi:6644730; -.
DR eggNOG; KOG4479; Eukaryota.
DR HOGENOM; CLU_134052_1_2_1; -.
DR InParanoid; B4N1G8; -.
DR OMA; IRDCIAT; -.
DR OrthoDB; 1538551at2759; -.
DR PhylomeDB; B4N1G8; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblMetazoa.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblMetazoa.
DR GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR GO; GO:0000124; C:SAGA complex; ISS:UniProtKB.
DR GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; IEA:EnsemblMetazoa.
DR GO; GO:0043035; F:chromatin insulator sequence binding; ISS:UniProtKB.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001094; F:TFIID-class transcription factor complex binding; IEA:EnsemblMetazoa.
DR GO; GO:0033696; P:heterochromatin boundary formation; IEA:EnsemblMetazoa.
DR GO; GO:0016578; P:histone deubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.246.140; -; 1.
DR HAMAP; MF_03046; ENY2_Sus1; 1.
DR InterPro; IPR018783; TF_ENY2.
DR InterPro; IPR038212; TF_EnY2_sf.
DR PANTHER; PTHR12514; PTHR12514; 1.
DR Pfam; PF10163; EnY2; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; Cytoplasm; mRNA transport; Nucleus;
KW Protein transport; Reference proteome; Transcription;
KW Transcription regulation; Translocation; Transport.
FT CHAIN 1..119
FT /note="Enhancer of yellow 2 transcription factor"
FT /id="PRO_0000367562"
FT REGION 93..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..119
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 119 AA; 13398 MW; 7F895472164888CE CRC64;
MTVSNTVDQY TVLTGDRSKI KDLLCNRLTE CGWRDEVRLL CRNILMEKAV AGAVTSNSNL
TLEQLITEVT PKARTLVPDA VKKELLMKIR TILTENETEG TDNHDDDEDD EDENGTEDN
