ID   ENY2_TAEGU              Reviewed;          96 AA.
AC   B5FZ63;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046};
DE   AltName: Full=Enhancer of yellow 2 transcription factor homolog {ECO:0000255|HAMAP-Rule:MF_03046};
GN   Name=ENY2 {ECO:0000255|HAMAP-Rule:MF_03046};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17018643; DOI=10.1073/pnas.0607098103;
RA   Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V.,
RA   Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S.,
RA   Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P.,
RA   Hayashizaki Y., Carninci P., Jarvis E.D.;
RT   "A molecular neuroethological approach for identifying and characterizing a
RT   cascade of behaviorally regulated genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006).
CC   -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC       association with both the TREX-2 and the SAGA complexes. The
CC       transcription regulatory histone acetylation (HAT) complex SAGA is a
CC       multiprotein complex that activates transcription by remodeling
CC       chromatin and mediating histone acetylation and deubiquitination.
CC       Within the SAGA complex, participates in a subcomplex that specifically
CC       deubiquitinates histones. The SAGA complex is recruited to specific
CC       gene promoters by activators, where it is required for transcription.
CC       The TREX-2 complex functions in docking export-competent
CC       ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC       nuclear pore complex (nuclear basket). TREX-2 participates in mRNA
CC       export and accurate chromatin positioning in the nucleus by tethering
CC       genes to the nuclear periphery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC       complex (transcription and export complex 2). Component of the SAGA
CC       transcription coactivator-HAT complex. Within the SAGA complex,
CC       participates in a subcomplex of SAGA called the DUB module
CC       (deubiquitination module) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
CC   -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
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DR   EMBL; DQ214330; ACH44324.1; -; mRNA.
DR   RefSeq; NP_001232138.1; NM_001245209.1.
DR   RefSeq; XP_002200405.1; XM_002200369.3.
DR   AlphaFoldDB; B5FZ63; -.
DR   SMR; B5FZ63; -.
DR   STRING; 59729.ENSTGUP00000034421; -.
DR   Ensembl; ENSTGUT00000019603; ENSTGUP00000034421; ENSTGUG00000026246.
DR   GeneID; 100190235; -.
DR   KEGG; tgu:100190235; -.
DR   CTD; 56943; -.
DR   GeneTree; ENSGT00390000011748; -.
DR   InParanoid; B5FZ63; -.
DR   OrthoDB; 1538551at2759; -.
DR   Proteomes; UP000007754; Chromosome 2.
DR   GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0044615; C:nuclear pore nuclear basket; IEA:Ensembl.
DR   GO; GO:0000124; C:SAGA complex; ISS:UniProtKB.
DR   GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0043966; P:histone H3 acetylation; IEA:Ensembl.
DR   GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; IEA:Ensembl.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.246.140; -; 1.
DR   HAMAP; MF_03046; ENY2_Sus1; 1.
DR   InterPro; IPR018783; TF_ENY2.
DR   InterPro; IPR038212; TF_EnY2_sf.
DR   PANTHER; PTHR12514; PTHR12514; 1.
DR   Pfam; PF10163; EnY2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; mRNA transport; Nucleus; Protein transport;
KW   Reference proteome; Transcription; Transcription regulation; Translocation;
KW   Transport.
FT   CHAIN           1..96
FT                   /note="Transcription and mRNA export factor ENY2"
FT                   /id="PRO_0000367546"
SQ   SEQUENCE   96 AA;  11000 MW;  AE3CB00E7D56515D CRC64;
     MNKDAQMRAT INQKLIETGE RERLKELLRA KLIECGWKDQ LKAHCKDVIK EKGLEHVTVD
     DLVAEITPKG RALVPDSVKK ELLQRIRTFL AQHASL