EOLA1_MOUSE
ID EOLA1_MOUSE Reviewed; 157 AA.
AC Q9D1F3; A2AF50; Q3TDX9;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein EOLA1 {ECO:0000250|UniProtKB:Q8TE69};
DE AltName: Full=Endothelial-overexpressed lipopolysaccharide-associated factor 1 {ECO:0000250|UniProtKB:Q8TE69};
DE AltName: Full=Endothelium and lymphocyte associated ASCH domain 1 {ECO:0000312|MGI:MGI:1915868};
GN Name=Eola1 {ECO:0000312|MGI:MGI:1915868};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0007744|PDB:6KIR, ECO:0007744|PDB:6KIS, ECO:0007744|PDB:6KIT}
RP X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).
RA Wu B.X.;
RT "High resolution structure of mouse CXorf40A.";
RL Submitted (JUL-2019) to the PDB data bank.
CC -!- FUNCTION: May play a role in cell protection during the inflammatory
CC response. In epithelial cells, negatively regulates IL6 production and
CC apoptosis through the regulation of MT2A expression.
CC {ECO:0000250|UniProtKB:Q8TE69}.
CC -!- SUBUNIT: Interacts with MT2A. {ECO:0000250|UniProtKB:Q8TE69}.
CC -!- SIMILARITY: Belongs to the EOLA family. {ECO:0000305}.
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DR EMBL; AK003642; BAB22908.1; -; mRNA.
DR EMBL; AK169935; BAE41469.1; -; mRNA.
DR EMBL; AL672026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024574; AAH24574.1; -; mRNA.
DR CCDS; CCDS30174.1; -.
DR RefSeq; NP_081063.1; NM_026787.2.
DR PDB; 6KIR; X-ray; 1.55 A; A=1-157.
DR PDB; 6KIS; X-ray; 1.54 A; A=1-157.
DR PDB; 6KIT; X-ray; 1.57 A; A=1-156.
DR PDBsum; 6KIR; -.
DR PDBsum; 6KIS; -.
DR PDBsum; 6KIT; -.
DR AlphaFoldDB; Q9D1F3; -.
DR SMR; Q9D1F3; -.
DR STRING; 10090.ENSMUSP00000052765; -.
DR EPD; Q9D1F3; -.
DR MaxQB; Q9D1F3; -.
DR PaxDb; Q9D1F3; -.
DR PRIDE; Q9D1F3; -.
DR DNASU; 68618; -.
DR Ensembl; ENSMUST00000053981; ENSMUSP00000052765; ENSMUSG00000045237.
DR GeneID; 68618; -.
DR KEGG; mmu:68618; -.
DR UCSC; uc009tjf.1; mouse.
DR CTD; 91966; -.
DR MGI; MGI:1915868; Eola1.
DR VEuPathDB; HostDB:ENSMUSG00000045237; -.
DR eggNOG; ENOG502RZ9S; Eukaryota.
DR GeneTree; ENSGT00390000012182; -.
DR HOGENOM; CLU_116791_0_0_1; -.
DR InParanoid; Q9D1F3; -.
DR OMA; QPYAGLI; -.
DR OrthoDB; 1215778at2759; -.
DR PhylomeDB; Q9D1F3; -.
DR TreeFam; TF332845; -.
DR BioGRID-ORCS; 68618; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q9D1F3; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D1F3; protein.
DR Bgee; ENSMUSG00000045237; Expressed in primary oocyte and 68 other tissues.
DR Genevisible; Q9D1F3; MM.
DR InterPro; IPR007374; ASCH_domain.
DR InterPro; IPR033615; EOLA1/EOLA2.
DR InterPro; IPR015947; PUA-like_sf.
DR PANTHER; PTHR31666; PTHR31666; 1.
DR Pfam; PF04266; ASCH; 1.
DR SMART; SM01022; ASCH; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..157
FT /note="Protein EOLA1"
FT /id="PRO_0000079734"
FT DOMAIN 6..92
FT /note="ASCH"
FT /evidence="ECO:0000255"
FT CONFLICT 125
FT /note="S -> P (in Ref. 1; BAE41469)"
FT /evidence="ECO:0000305"
FT STRAND 1..10
FT /evidence="ECO:0007829|PDB:6KIS"
FT HELIX 12..17
FT /evidence="ECO:0007829|PDB:6KIS"
FT STRAND 23..28
FT /evidence="ECO:0007829|PDB:6KIS"
FT HELIX 30..34
FT /evidence="ECO:0007829|PDB:6KIS"
FT STRAND 37..47
FT /evidence="ECO:0007829|PDB:6KIS"
FT HELIX 53..59
FT /evidence="ECO:0007829|PDB:6KIS"
FT HELIX 65..75
FT /evidence="ECO:0007829|PDB:6KIS"
FT TURN 76..78
FT /evidence="ECO:0007829|PDB:6KIS"
FT STRAND 80..94
FT /evidence="ECO:0007829|PDB:6KIS"
FT HELIX 101..111
FT /evidence="ECO:0007829|PDB:6KIS"
FT STRAND 120..135
FT /evidence="ECO:0007829|PDB:6KIS"
FT STRAND 140..147
FT /evidence="ECO:0007829|PDB:6KIS"
FT HELIX 149..151
FT /evidence="ECO:0007829|PDB:6KIS"
SQ SEQUENCE 157 AA; 18059 MW; C0C7D33EA4468DB5 CRC64;
MKFPCLSFRQ PYAGLILNGV KTLETRWRPL LSSVQKYTIA IHIAHKDWED DEWQEVLMER
LGMTWTQIQT LLQAGEKYGR GVIAGLIDIG ETFQCPETLT AEEAVELETQ AVLTNLQLKY
LTQVSNPRWL LEPIPRKGGK DIFQVDIPEH LIPLEKE
