ID   EOLA2_HUMAN             Reviewed;         158 AA.
AC   Q96DE9;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Protein EOLA2 {ECO:0000305};
DE   AltName: Full=Protein CXorf40B;
GN   Name=EOLA2 {ECO:0000312|HGNC:HGNC:17402}; Synonyms=CXorf40B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8717057; DOI=10.1101/gr.5.1.71;
RA   Timms K.M., Lu F., Shen Y., Pierson C.A., Muzny D.M., Gu Y., Nelson D.L.,
RA   Gibbs R.A.;
RT   "130 kb of DNA sequence reveals two new genes and a regional duplication
RT   distal to the human iduronate-2-sulfate sulfatase locus.";
RL   Genome Res. 5:71-78(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the EOLA family. {ECO:0000305}.
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DR   EMBL; L43575; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BX927209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC009523; AAH09523.1; -; mRNA.
DR   CCDS; CCDS35426.1; -.
DR   RefSeq; NP_001013867.1; NM_001013845.1.
DR   RefSeq; XP_005274755.1; XM_005274698.1.
DR   RefSeq; XP_005274756.1; XM_005274699.1.
DR   RefSeq; XP_005274757.1; XM_005274700.1.
DR   RefSeq; XP_005274758.1; XM_005274701.2.
DR   RefSeq; XP_005274759.1; XM_005274702.3.
DR   RefSeq; XP_006724889.1; XM_006724826.3.
DR   RefSeq; XP_011529482.1; XM_011531180.2.
DR   RefSeq; XP_016885074.1; XM_017029585.1.
DR   RefSeq; XP_016885075.1; XM_017029586.1.
DR   RefSeq; XP_016885076.1; XM_017029587.1.
DR   RefSeq; XP_016885077.1; XM_017029588.1.
DR   RefSeq; XP_016885078.1; XM_017029589.1.
DR   AlphaFoldDB; Q96DE9; -.
DR   SMR; Q96DE9; -.
DR   STRING; 9606.ENSP00000359434; -.
DR   BioMuta; CXorf40B; -.
DR   DMDM; 68052373; -.
DR   EPD; Q96DE9; -.
DR   MassIVE; Q96DE9; -.
DR   MaxQB; Q96DE9; -.
DR   PaxDb; Q96DE9; -.
DR   PRIDE; Q96DE9; -.
DR   ProteomicsDB; 76285; -.
DR   Antibodypedia; 76734; 27 antibodies from 6 providers.
DR   DNASU; 541578; -.
DR   Ensembl; ENST00000355203.6; ENSP00000347339.2; ENSG00000197021.9.
DR   Ensembl; ENST00000370404.5; ENSP00000359432.1; ENSG00000197021.9.
DR   Ensembl; ENST00000370406.8; ENSP00000359434.3; ENSG00000197021.9.
DR   GeneID; 541578; -.
DR   KEGG; hsa:541578; -.
DR   MANE-Select; ENST00000370406.8; ENSP00000359434.3; NM_001013845.2; NP_001013867.1.
DR   UCSC; uc004fdy.4; human.
DR   CTD; 541578; -.
DR   GeneCards; EOLA2; -.
DR   HGNC; HGNC:17402; EOLA2.
DR   HPA; ENSG00000197021; Low tissue specificity.
DR   neXtProt; NX_Q96DE9; -.
DR   OpenTargets; ENSG00000197021; -.
DR   VEuPathDB; HostDB:ENSG00000197021; -.
DR   eggNOG; ENOG502RZ9S; Eukaryota.
DR   GeneTree; ENSGT00390000012182; -.
DR   InParanoid; Q96DE9; -.
DR   OMA; WHCTLAV; -.
DR   PhylomeDB; Q96DE9; -.
DR   TreeFam; TF332845; -.
DR   PathwayCommons; Q96DE9; -.
DR   SignaLink; Q96DE9; -.
DR   BioGRID-ORCS; 541578; 18 hits in 617 CRISPR screens.
DR   ChiTaRS; CXorf40B; human.
DR   GenomeRNAi; 541578; -.
DR   Pharos; Q96DE9; Tdark.
DR   PRO; PR:Q96DE9; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q96DE9; protein.
DR   Bgee; ENSG00000197021; Expressed in granulocyte and 96 other tissues.
DR   ExpressionAtlas; Q96DE9; baseline and differential.
DR   Genevisible; Q96DE9; HS.
DR   InterPro; IPR007374; ASCH_domain.
DR   InterPro; IPR033615; EOLA1/EOLA2.
DR   InterPro; IPR015947; PUA-like_sf.
DR   PANTHER; PTHR31666; PTHR31666; 1.
DR   SMART; SM01022; ASCH; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..158
FT                   /note="Protein EOLA2"
FT                   /id="PRO_0000079741"
FT   DOMAIN          6..92
FT                   /note="ASCH"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   158 AA;  17780 MW;  DC14535A4816F652 CRC64;
     MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG DACRELLVER
     LGMTPAQIQA LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT PDEVVELENQ AALTNLKQKY
     LTVISNPRWL LEPIPRKGGK DVFQVDIPEH LIPLGHEV