ID   EOMES_XENLA             Reviewed;         692 AA.
AC   P79944;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Eomesodermin;
GN   Name=eomes;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND INDUCTION.
RC   TISSUE=Embryo;
RX   PubMed=8978604; DOI=10.1016/s0092-8674(00)81794-8;
RA   Ryan K., Garrett N., Mitchell A., Gurdon J.B.;
RT   "Eomesodermin, a key early gene in Xenopus mesoderm differentiation.";
RL   Cell 87:989-1000(1996).
RN   [2]
RP   INDUCTION.
RX   PubMed=10068640; DOI=10.1242/dev.126.7.1467;
RA   Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R.,
RA   DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L.;
RT   "derriere: a TGF-beta family member required for posterior development in
RT   Xenopus.";
RL   Development 126:1467-1482(1999).
RN   [3]
RP   FUNCTION.
RX   PubMed=11585801; DOI=10.1242/dev.128.19.3749;
RA   Conlon F.L., Fairclough L., Price B.M.J., Casey E.S., Smith J.C.;
RT   "Determinants of T box protein specificity.";
RL   Development 128:3749-3758(2001).
CC   -!- FUNCTION: Functions as a transcriptional activator playing a crucial
CC       role during development. Functions in gastrulation, regulating mesoderm
CC       differentiation. Activates wnt8, t/bra, chrd and mix-A/mix.1
CC       expression. {ECO:0000269|PubMed:11585801, ECO:0000269|PubMed:8978604}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: First expressed at or just after midblastula
CC       transition (stage 8). Maximally expressed at stage 10 as an equitorial
CC       mesoderm band, more prominently on the dorsal side and around the
CC       invaginating dorsal lip. {ECO:0000269|PubMed:8978604}.
CC   -!- INDUCTION: By activin and derriere. {ECO:0000269|PubMed:10068640,
CC       ECO:0000269|PubMed:8978604}.
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DR   EMBL; U75996; AAC60061.1; -; mRNA.
DR   RefSeq; NP_001081810.1; NM_001088341.1.
DR   AlphaFoldDB; P79944; -.
DR   SMR; P79944; -.
DR   PRIDE; P79944; -.
DR   DNASU; 398065; -.
DR   GeneID; 398065; -.
DR   KEGG; xla:398065; -.
DR   CTD; 398065; -.
DR   Xenbase; XB-GENE-865305; eomes.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001706; P:endoderm formation; ISS:UniProtKB.
DR   GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR032385; T-box_assoc.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   Pfam; PF16176; T-box_assoc; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Gastrulation; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..692
FT                   /note="Eomesodermin"
FT                   /id="PRO_0000184461"
FT   DNA_BIND        263..443
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          35..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          578..692
FT                   /note="Required for transcription activation"
FT   REGION          595..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          621..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        625..642
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..666
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   692 AA;  75943 MW;  9D129A67F6357989 CRC64;
     MVPGAWHSLL FTTSSASEKE ENRSQRMQLG EQLLNSSTPN LPHTFYPLTG DPSSAVHSPS
     LEFSVGHKGQ QHKKYSSGSS RGLQLDSPRE AGSSSTMLSE TGEGFSVAKT LPDNVRKGSP
     SAEEELNTAV PTSAPRYLDG SLQAASERYY LQPQGQQLQQ TTTELGSPCS IFPYAPPQHS
     AVYPAGGAAR YPPYGSMLPP AGFSPPVCPS RPQYSSGYQY SQAPGTMYSP YPPAGTGSGL
     SALGLPGGGA GVRAQVFLCN RPLWLKFHRH QTEMIITKQG RRMFPFLSFN ITGLNPTAHY
     NVFVEVVLAD PNHWRFQGGK WVTCGKADNN MQGNKVYVHP ESPNTGAHWM RQEISFGKLK
     LTNNKGANNN STQMIVLQSL HKYQPRLHIV EVSEDGVEDL NDSAKNQTFT FPENQFIAVT
     AYQNTDITQL KIDHNPFAKG FRDNYDSMYT ASESDRLTPS PADSPRSHQI VPGTRYSVQP
     FFQDQFVNNL PPARYYSGER TVPQANGLLS PQTNEEVANV PPQRWFVTPV QQAAANKLDM
     GAYETDYSSG SLLTYGIKSL PIQTSHPMAY YPDAAFASMA GWGSRGSTYQ RKMTTSLPWS
     SRSSPSGFSE DLLPKDKVKE EMSSSWVETP PSIKSLDSND SGVYTGACKR RRLSPSTSSN
     ENSPPIKCED IGTEDYKDAT KGLGYYSFYS SS