ID   EP3A_HUMAN              Reviewed;         147 AA.
AC   Q14507; Q4KN33;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Epididymal secretory protein E3-alpha;
DE   AltName: Full=Human epididymis-specific protein 3-alpha;
DE            Short=HE3-alpha;
DE   Flags: Precursor;
GN   Name=EDDM3A; Synonyms=FAM12A, HE3A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Epididymis;
RX   PubMed=7514008; DOI=10.1002/mrd.1080370203;
RA   Kirchhoff C., Pera I., Rust W., Ivell R.;
RT   "Major human epididymis-specific gene product, HE3, is the first
RT   representative of a novel gene family.";
RL   Mol. Reprod. Dev. 37:130-137(1994).
RN   [2]
RP   SEQUENCE REVISION.
RA   Kirchhoff C.;
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Possible function in sperm maturation.
CC   -!- INTERACTION:
CC       Q14507; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-17953459, EBI-17953245;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Epididymis, with predominant expression in the
CC       corpus region. Moderately expressed in the vas deferens; only low
CC       levels are detectable in the caput and cauda regions.
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DR   EMBL; X76383; CAA53971.2; -; mRNA.
DR   EMBL; X76385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069407; AAH69407.1; -; mRNA.
DR   EMBL; BC096698; AAH96698.1; -; mRNA.
DR   EMBL; BC096731; AAH96731.1; -; mRNA.
DR   EMBL; BC098164; AAH98164.1; -; mRNA.
DR   EMBL; BC098356; AAH98356.1; -; mRNA.
DR   EMBL; BC106711; AAI06712.1; -; mRNA.
DR   EMBL; BC106712; AAI06713.1; -; mRNA.
DR   CCDS; CCDS9556.1; -.
DR   PIR; I37455; S42795.
DR   RefSeq; NP_006674.2; NM_006683.4.
DR   RefSeq; XP_016876423.1; XM_017020934.1.
DR   AlphaFoldDB; Q14507; -.
DR   SMR; Q14507; -.
DR   BioGRID; 116084; 39.
DR   IntAct; Q14507; 2.
DR   STRING; 9606.ENSP00000315098; -.
DR   iPTMnet; Q14507; -.
DR   PhosphoSitePlus; Q14507; -.
DR   BioMuta; EDDM3A; -.
DR   DMDM; 14916983; -.
DR   MassIVE; Q14507; -.
DR   PaxDb; Q14507; -.
DR   PeptideAtlas; Q14507; -.
DR   PRIDE; Q14507; -.
DR   ProteomicsDB; 60009; -.
DR   Antibodypedia; 64052; 19 antibodies from 9 providers.
DR   DNASU; 10876; -.
DR   Ensembl; ENST00000326842.3; ENSP00000315098.2; ENSG00000181562.5.
DR   GeneID; 10876; -.
DR   KEGG; hsa:10876; -.
DR   MANE-Select; ENST00000326842.3; ENSP00000315098.2; NM_006683.5; NP_006674.2.
DR   CTD; 10876; -.
DR   DisGeNET; 10876; -.
DR   GeneCards; EDDM3A; -.
DR   HGNC; HGNC:16978; EDDM3A.
DR   HPA; ENSG00000181562; Tissue enriched (epididymis).
DR   MIM; 611580; gene.
DR   neXtProt; NX_Q14507; -.
DR   OpenTargets; ENSG00000181562; -.
DR   PharmGKB; PA165478869; -.
DR   VEuPathDB; HostDB:ENSG00000181562; -.
DR   eggNOG; ENOG502RWFV; Eukaryota.
DR   GeneTree; ENSGT00390000004706; -.
DR   InParanoid; Q14507; -.
DR   OMA; GKSSHMF; -.
DR   OrthoDB; 1426327at2759; -.
DR   PhylomeDB; Q14507; -.
DR   TreeFam; TF314795; -.
DR   PathwayCommons; Q14507; -.
DR   SignaLink; Q14507; -.
DR   BioGRID-ORCS; 10876; 8 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 10876; -.
DR   Pharos; Q14507; Tdark.
DR   PRO; PR:Q14507; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q14507; protein.
DR   Bgee; ENSG00000181562; Expressed in corpus epididymis and 20 other tissues.
DR   ExpressionAtlas; Q14507; baseline and differential.
DR   Genevisible; Q14507; HS.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0007321; P:sperm displacement; TAS:ProtInc.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029747; EDDM3A.
DR   InterPro; IPR042402; EDDM3A/EDDM3B.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR16788; PTHR16788; 1.
DR   PANTHER; PTHR16788:SF4; PTHR16788:SF4; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..147
FT                   /note="Epididymal secretory protein E3-alpha"
FT                   /id="PRO_0000021188"
FT   VARIANT         62
FT                   /note="G -> C (in dbSNP:rs34552133)"
FT                   /id="VAR_050968"
SQ   SEQUENCE   147 AA;  17646 MW;  3C700AEB01793A44 CRC64;
     MTSSLKIWGI LLALLCILCR LCVYSNNIYW REFIKLHYLS PSREFKEYKC DVLMREKEAL
     KGKSFHMFIY SLWFKIQRAC INEKGSDRYR NAYVWAPGAL KVLECHWEKY NNRYTESRSF
     SYIEFHCGVD GYVDNIEDLR IIEPISN