EP3B_HUMAN
ID EP3B_HUMAN Reviewed; 147 AA.
AC P56851; A0PK89;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Epididymal secretory protein E3-beta;
DE AltName: Full=Human epididymis-specific protein 3-beta;
DE Short=HE3-beta;
DE Flags: Precursor;
GN Name=EDDM3B; Synonyms=FAM12B, HE3B; ORFNames=UNQ6412/PRO21187;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epididymis;
RX PubMed=7514008; DOI=10.1002/mrd.1080370203;
RA Kirchhoff C., Pera I., Rust W., Ivell R.;
RT "Major human epididymis-specific gene product, HE3, is the first
RT representative of a novel gene family.";
RL Mol. Reprod. Dev. 37:130-137(1994).
RN [2]
RP SEQUENCE REVISION.
RA Kirchhoff C.;
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-5.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible function in sperm maturation.
CC -!- INTERACTION:
CC P56851; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-10215665, EBI-19125216;
CC P56851; P04233-2: CD74; NbExp=3; IntAct=EBI-10215665, EBI-12222807;
CC P56851; P11912: CD79A; NbExp=3; IntAct=EBI-10215665, EBI-7797864;
CC P56851; O95471: CLDN7; NbExp=3; IntAct=EBI-10215665, EBI-740744;
CC P56851; P10176: COX8A; NbExp=3; IntAct=EBI-10215665, EBI-3904738;
CC P56851; O15552: FFAR2; NbExp=3; IntAct=EBI-10215665, EBI-2833872;
CC P56851; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-10215665, EBI-12142257;
CC P56851; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10215665, EBI-13345167;
CC P56851; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10215665, EBI-11721746;
CC P56851; P32942: ICAM3; NbExp=3; IntAct=EBI-10215665, EBI-725421;
CC P56851; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-10215665, EBI-465137;
CC P56851; P48051: KCNJ6; NbExp=3; IntAct=EBI-10215665, EBI-12017638;
CC P56851; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-10215665, EBI-17272405;
CC P56851; Q8N386: LRRC25; NbExp=3; IntAct=EBI-10215665, EBI-11304917;
CC P56851; Q96AG4: LRRC59; NbExp=3; IntAct=EBI-10215665, EBI-358888;
CC P56851; P15941-11: MUC1; NbExp=3; IntAct=EBI-10215665, EBI-17263240;
CC P56851; P15151: PVR; NbExp=3; IntAct=EBI-10215665, EBI-3919694;
CC P56851; Q96L08: SUSD3; NbExp=3; IntAct=EBI-10215665, EBI-18194029;
CC P56851; Q8N205: SYNE4; NbExp=3; IntAct=EBI-10215665, EBI-7131783;
CC P56851; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-10215665, EBI-2821497;
CC P56851; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-10215665, EBI-12345267;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Epididymis.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X76386; CAC17141.1; -; mRNA.
DR EMBL; AY358865; AAQ89224.1; -; mRNA.
DR EMBL; BC128030; AAI28031.1; -; mRNA.
DR CCDS; CCDS9557.1; -.
DR RefSeq; NP_071755.1; NM_022360.4.
DR AlphaFoldDB; P56851; -.
DR SMR; P56851; -.
DR BioGRID; 122100; 68.
DR IntAct; P56851; 22.
DR STRING; 9606.ENSP00000314810; -.
DR iPTMnet; P56851; -.
DR PhosphoSitePlus; P56851; -.
DR BioMuta; EDDM3B; -.
DR DMDM; 14916988; -.
DR MassIVE; P56851; -.
DR PaxDb; P56851; -.
DR PeptideAtlas; P56851; -.
DR PRIDE; P56851; -.
DR ProteomicsDB; 56952; -.
DR Antibodypedia; 24; 23 antibodies from 12 providers.
DR DNASU; 64184; -.
DR Ensembl; ENST00000326783.4; ENSP00000314810.3; ENSG00000181552.4.
DR GeneID; 64184; -.
DR KEGG; hsa:64184; -.
DR MANE-Select; ENST00000326783.4; ENSP00000314810.3; NM_022360.5; NP_071755.1.
DR CTD; 64184; -.
DR DisGeNET; 64184; -.
DR GeneCards; EDDM3B; -.
DR HGNC; HGNC:19223; EDDM3B.
DR HPA; ENSG00000181552; Tissue enriched (epididymis).
DR MIM; 611582; gene.
DR neXtProt; NX_P56851; -.
DR OpenTargets; ENSG00000181552; -.
DR PharmGKB; PA165478900; -.
DR VEuPathDB; HostDB:ENSG00000181552; -.
DR eggNOG; ENOG502RWFV; Eukaryota.
DR GeneTree; ENSGT00390000004706; -.
DR HOGENOM; CLU_148772_0_0_1; -.
DR InParanoid; P56851; -.
DR OMA; HKIEHIC; -.
DR OrthoDB; 1426327at2759; -.
DR PhylomeDB; P56851; -.
DR TreeFam; TF314795; -.
DR PathwayCommons; P56851; -.
DR SignaLink; P56851; -.
DR BioGRID-ORCS; 64184; 22 hits in 1067 CRISPR screens.
DR GenomeRNAi; 64184; -.
DR Pharos; P56851; Tdark.
DR PRO; PR:P56851; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P56851; protein.
DR Bgee; ENSG00000181552; Expressed in corpus epididymis and 14 other tissues.
DR ExpressionAtlas; P56851; baseline and differential.
DR Genevisible; P56851; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR042402; EDDM3A/EDDM3B.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR16788; PTHR16788; 1.
DR Pfam; PF00074; RnaseA; 1.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..147
FT /note="Epididymal secretory protein E3-beta"
FT /id="PRO_0000021189"
FT VARIANT 5
FT /note="L -> V (in dbSNP:rs3827906)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038946"
SQ SEQUENCE 147 AA; 17584 MW; 022367C7BA0C2708 CRC64;
MASSLKIWGT LLALLCILCT LLVQSKEVSW REFMKQHYLS PSREFREYKC DVLMRENEAL
KDKSSHMFIY ISWYKIEHIC TSDNWMDRFR NAYVWVQNPL KVLKCHQENS KNSYTESRSF
NYIEFHCSMD GYVDSIEDLK MVEPIGN
