ID   EP45_XENLA              Reviewed;         436 AA.
AC   Q00387; B7ZSE2;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Serine protease inhibitor A6;
DE            Short=Serpin A6;
DE   AltName: Full=Estrogen-regulated protein EP45;
DE   Flags: Precursor;
GN   Name=serpina6; Synonyms=ep45;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   INDUCTION.
RC   TISSUE=Hepatocyte;
RX   PubMed=1551912; DOI=10.1016/s0021-9258(19)50535-x;
RA   Holland L.J., Suksang C., Wall A.A., Roberts L.R., Moser D.R.,
RA   Bhattacharya A.;
RT   "A major estrogen-regulated protein secreted from the liver of Xenopus
RT   laevis is a member of the serpin superfamily. Nucleotide sequence of cDNA
RT   and hormonal induction of mRNA.";
RL   J. Biol. Chem. 267:7053-7059(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Not yet known.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000269|PubMed:1551912}.
CC   -!- TISSUE SPECIFICITY: Liver. {ECO:0000269|PubMed:1551912}.
CC   -!- INDUCTION: By estrogen. {ECO:0000269|PubMed:1551912}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; M76410; AAA49703.1; -; mRNA.
DR   EMBL; BC170492; AAI70492.1; -; mRNA.
DR   EMBL; BC170494; AAI70494.1; -; mRNA.
DR   PIR; A42440; A42440.
DR   RefSeq; NP_001079103.1; NM_001085634.1.
DR   AlphaFoldDB; Q00387; -.
DR   SMR; Q00387; -.
DR   ABCD; Q00387; 1 sequenced antibody.
DR   GeneID; 373636; -.
DR   KEGG; xla:373636; -.
DR   CTD; 373636; -.
DR   Xenbase; XB-GENE-6252882; serpina6.L.
DR   OMA; IMFLNIS; -.
DR   OrthoDB; 1124079at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 373636; Expressed in liver and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..436
FT                   /note="Serine protease inhibitor A6"
FT                   /id="PRO_0000032536"
FT   REGION          26..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        260
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        289
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        297
FT                   /note="V -> F (in Ref. 1; AAA49703)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   436 AA;  49523 MW;  A0A229D415FAE6C1 CRC64;
     MHLLVYLSLF FALALASVTE ISLDNKHRHR HEQQGHHDSA KHGHQKDKQQ QEQIKNDEGK
     LTKEEKILSE ENSDFSVNLF NQLSTESKRS PRKNIFFSPI SISAAFYMLA LGAKSETHQQ
     ILKGLSFNKK KLSESQVHEA FKRLIEDSNN PMKAHQFTIG NALFVEQTVN ILKGFEENVK
     HYYQAGVFPM NFKDPDNAKK QLNNYVKDKT HGVIQEMIRE LDSNTEMVLV NYVLYKGEWA
     NNFNPTLTQK SLFSVDKNTN VTVQMMNRLG LYRTYQDDDC KIIELPYKND TAMLLVVPQL
     GKIQELVLTS KLINHWYESL ATSIVDLYMP TFSISGKVVL KDTLRKMGIS DIFTDKADLT
     GISEQIKLKV SMASHNAVLN VNEFGTEAVG ATSAQASPTK LFPPFLIDSP FLVMIYSRTL
     GSQLFMGKVM DPTNAQ