EP84_HCMVM
ID EP84_HCMVM Reviewed; 684 AA.
AC Q6SW37; D2K3R3;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 47.
DE RecName: Full=Early phosphoprotein p84;
GN Name=UL112/UL113;
OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=295027;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
CC -!- FUNCTION: Needed for efficient replication. Recruits the DNA polymerase
CC processivity factor to pre-replication foci.
CC -!- SUBUNIT: Isoforms 1, 2, 3 and 4 interacts with themselves and with each
CC other via their shared N-terminal regions; these interactions are
CC important to both their intranuclear targeting and the recruitment of
CC UL44 to subnuclear sites for viral replication.
CC -!- SUBCELLULAR LOCATION: Host nucleus. Virion. Note=Found in subnuclear
CC structures known as promyelocytic leukemia oncogenic domains (PODs) or
CC nuclear domain 10 (ND10) during the early.
CC {ECO:0000250|UniProtKB:P17151}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Comment=Isoforms 1, 2, 3 and 4 share a common N-terminus.;
CC Name=p84; Synonyms=84 kDa phosphoprotein;
CC IsoId=Q6SW37-1; Sequence=Displayed;
CC Name=p50; Synonyms=50 kDa phosphoprotein;
CC IsoId=Q6SW37-2; Sequence=VSP_042762, VSP_042765;
CC Name=p43; Synonyms=43 kDa phosphoprotein;
CC IsoId=Q6SW37-3; Sequence=VSP_042763, VSP_042764;
CC Name=p34; Synonyms=34 kDa phosphoprotein;
CC IsoId=Q6SW37-4; Sequence=VSP_042760, VSP_042761;
CC -!- MISCELLANEOUS: [Isoform p43]: Most abundant product which level of
CC expression remains constant throughout infection. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the herpesviridae U79/UL112 family.
CC {ECO:0000305}.
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DR EMBL; AY446894; AAR31657.1; -; Genomic_DNA.
DR RefSeq; YP_081553.1; NC_006273.2.
DR SMR; Q6SW37; -.
DR PRIDE; Q6SW37; -.
DR GeneID; 3077495; -.
DR KEGG; vg:3077495; -.
DR Reactome; R-HSA-9609690; HCMV Early Events.
DR Reactome; R-HSA-9610379; HCMV Late Events.
DR Proteomes; UP000000938; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR InterPro; IPR004138; U79_P34.
DR Pfam; PF03064; U79_P34; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Early protein; Host nucleus; Phosphoprotein;
KW Reference proteome; Virion.
FT CHAIN 1..684
FT /note="Early phosphoprotein p84"
FT /id="PRO_0000416710"
FT REGION 166..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 261..264
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 177..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 254..268
FT /note="SPPLREAKRQKTTAQ -> ESRPSSRHGAFRVDS (in isoform p34)"
FT /evidence="ECO:0000305"
FT /id="VSP_042760"
FT VAR_SEQ 269..684
FT /note="Missing (in isoform p34)"
FT /evidence="ECO:0000305"
FT /id="VSP_042761"
FT VAR_SEQ 346..423
FT /note="GALLLPIERGAVVSSPSSTSPSSLLSLPRPSSAHSAGETVQESEAAATAAAA
FT GLMMMRRMRRAPAEAAEAPPQSEEEN -> DSCQRRRAGLSSSTTAASRGPPQLSPQPA
FT LAPQQSHVRHSSPPVLYPQVPSPVSRPLPPQSKHQLLLPGPCVKSSPTW (in
FT isoform p50)"
FT /evidence="ECO:0000305"
FT /id="VSP_042762"
FT VAR_SEQ 347..358
FT /note="ALLLPIERGAVV -> IRGASASSQSAF (in isoform p43)"
FT /evidence="ECO:0000305"
FT /id="VSP_042763"
FT VAR_SEQ 359..684
FT /note="Missing (in isoform p43)"
FT /evidence="ECO:0000305"
FT /id="VSP_042764"
FT VAR_SEQ 424..684
FT /note="Missing (in isoform p50)"
FT /evidence="ECO:0000305"
FT /id="VSP_042765"
SQ SEQUENCE 684 AA; 70270 MW; AF3B43A4D56B7E01 CRC64;
MDLPTTVVRK YWTFTNPNRI LHQSVNQTFD VRQFVFDNAR LVNCVDGDGK VLHLNKGWLC
ATIMQHGEAS AGAKTQQGFM SIDITGDGEL QEHLFVRGGI VFNKSVSSVV GSSGPNESAL
LTMISENGNL QVTYVRHYLK NHGESSGGGG GCGAASTASA VCVSSLGGSG GTRDGPSAEE
QQRRRQEQRH EERRKKSSSS AGGGGGGGAS GGGGGGGSGG QHSSDSANGL LRDPRLMNRQ
KERRPPPSSE NDGSPPLREA KRQKTTAQHE GHGGGGKNET EQQSGGAGGG GGGGSGRMSL
PLDTSEAVAF LNYSSSSSAV SSSSNNHHHH HHHHNAVTDV AAGTDGALLL PIERGAVVSS
PSSTSPSSLL SLPRPSSAHS AGETVQESEA AATAAAAGLM MMRRMRRAPA EAAEAPPQSE
EENDSTTPVS NCRVPPNSQE SAAPQPPRSP RFDDIIQSLT KMLNDCKEKR LCDLPLVSSR
LLPETSGGTV VVNHSSVART AAAVSTAGVG PPAVACPPLV TTGVVPSGSV AGVAPVAAAV
ETPAAPPRPV CEIKPYVVNP VVATAAAASN SSSSSSAPLP PPPPPPGGRR GRARNNTRGG
GGGGGGGRNS RRQAASSSSS SSRRSRRRNN RHEDEDNDPL LRLSQVAGSG RRRGPSFLED
GLEIIDPSEE AAIAAASIAA FFDD
