ID   AGO12_ORYSJ             Reviewed;        1049 AA.
AC   Q7Y001; Q0DPL4; Q10F40;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein argonaute 12;
DE            Short=OsAGO12;
GN   Name=AGO12; OrderedLocusNames=Os03g0682200, LOC_Os03g47820;
GN   ORFNames=OSJNBb0070O09.6;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA   Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA   Kapoor S.;
RT   "Genome-wide identification, organization and phylogenetic analysis of
RT   dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT   their expression analysis during reproductive development and stress in
RT   rice.";
RL   BMC Genomics 9:451-451(2008).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC       short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC       (siRNAs), and represses the translation of mRNAs which are
CC       complementary to them (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP68386.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=ABF98225.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAF12824.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC087412; AAP68386.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DP000009; ABF98225.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008209; BAF12824.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q7Y001; -.
DR   SMR; Q7Y001; -.
DR   STRING; 4530.OS03T0682200-00; -.
DR   PaxDb; Q7Y001; -.
DR   PRIDE; Q7Y001; -.
DR   eggNOG; KOG1041; Eukaryota.
DR   InParanoid; Q7Y001; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR   CDD; cd04657; Piwi_ago-like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032472; ArgoL2.
DR   InterPro; IPR032473; Argonaute_Mid_dom.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR045246; Piwi_ago-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16488; ArgoL2; 1.
DR   Pfam; PF16487; ArgoMid; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..1049
FT                   /note="Protein argonaute 12"
FT                   /id="PRO_0000378435"
FT   DOMAIN          403..515
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          694..1012
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1049 AA;  115246 MW;  A327090B07B086EF CRC64;
     MSSRGGGGGG RRGGRGGGGG REGGGGGGGG GGRGGQGRGD LGVVGERQGG GRGAGERGGR
     HDAPRGRGGV AVGAGAGRQQ QQPFHAPAPP SGGGGRGGVQ VQPNAAARRP VGGGRGGVGV
     PAPAPAVAVG ALCGEMKGKM VVSGGAPPAG QGSSLAAAQG TDNVKREPSQ VAAPAPAPPP
     ATLPPSSSKA VTFPARPDVG TIGRRCRVRA NHFLVQVADK DIYHYDVVIT PESTYRERNR
     SIINKLVALH KQFLDGRLPV YDGRKSIYTA GPLPFKTKDF VVKHINPLRG NQREEEYKVT
     IKQASKTDLY SLKQFLVGRQ RELPQDTIQA LDIALRECPT SVNFTCDRYV SISRSFFSQS
     FGHGGEIGSG TECWRGYYQS LRPTQMGLSL NIDISATAFY KAQPVMDFAV QYLNIRDVSR
     RLSDQDRIKL KKALKGVQIV ATHWKEKSIR YKITGIPSAP MNELMFDLDG NRISVVQYFK
     KQYNYSLKHV NWPCLQAGSD SRPKYLPMEV CSILEGQRYS KKLNEHQVTN ILRMTCERPA
     QRESSIIEIV NTNSYGNDDC AKEFGIKVAN QLAVVDARVL PTPRLKYHDS GREKVCNPSV
     GQWNMINKRM VNGGCINHWT CLSFASRMHV NDIRMFCEDL VGMCNNIGMQ MNTRPCVDII
     QGQQRNIEGA IRNIHRQSSE KLDQQDLTGQ QLQLLIVILT EISGSYGRIK RICETEVGVI
     TQCCAPKSLQ KGGKQYLENL ALKMNVKVGG RNTVLEDALH KKIPILTDRP TIVFGADVTH
     PSPGEDASPS IAAVVASMDW PEVTKYKCLV STQSHREEII SNLYTEVKDP LKGIIRGGMI
     RELLRSFYQE TGQKPSRIIF YRDGISEGQF SQVLLYEMDA IRKACASLQE GYLPPVTFVV
     VQKRHHTRLF PENRRDMMDR SGNILPGTVV DTMICHPSEF DFYLCSHSGI KGTSRPTHYH
     VLLDENGFKA DTLQTLTYNL SYTYARCTRA VSIVPPAYYA HLGAFRARYY MEDEHSDQGS
     SSSVTTRTDR STKPLPEIKE NVKRFMFYC