EPAB2_MOUSE
ID EPAB2_MOUSE Reviewed; 273 AA.
AC Q5XFR0; B9EJ43;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Embryonic polyadenylate-binding protein 2;
DE Short=Embryonic poly(A)-binding protein 2;
DE Short=ePABP-2;
DE Short=ePABP2;
DE AltName: Full=Embryonic poly(A)-binding protein type II;
DE AltName: Full=Poly(A)-binding protein nuclear-like 1;
GN Name=Pabpn1l; Synonyms=Epabp2, Gm1108, Pabpnl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-207 AND 229-273.
RC STRAIN=C57BL/6J {ECO:0000269|PubMed:10922068};
RX PubMed=10922068; DOI=10.1073/pnas.97.16.9127;
RA Tanaka T.S., Jaradat S.A., Lim M.K., Kargul G.J., Wang X., Grahovac M.J.,
RA Pantano S., Sano Y., Piao Y., Nagaraja R., Doi H., Wood W.H. III,
RA Becker K.G., Ko M.S.H.;
RT "Genome-wide expression profiling of mid-gestation placenta and embryo
RT using a 15,000 mouse developmental cDNA microarray.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9127-9132(2000).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-154 AND 183-273.
RC STRAIN=C57BL/6J {ECO:0000269|PubMed:11544199};
RC TISSUE=Egg {ECO:0000269|PubMed:11544199};
RX PubMed=11544199; DOI=10.1101/gr.185501;
RA Piao Y., Ko N.T., Lim M.K., Ko M.S.H.;
RT "Construction of long-transcript enriched cDNA libraries from submicrogram
RT amounts of total RNAs by a universal PCR amplification method.";
RL Genome Res. 11:1553-1558(2001).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 161-273.
RC STRAIN=C57BL/6J {ECO:0000269|PubMed:10725249};
RC TISSUE=Embryo {ECO:0000269|PubMed:10725249};
RX PubMed=10725249; DOI=10.1242/dev.127.8.1737;
RA Ko M.S.H., Kitchen J.R., Wang X., Threat T.A., Wang X., Hasegawa A.,
RA Sun T., Grahovac M.J., Kargul G.J., Lim M.K., Cui Y., Sano Y., Tanaka T.S.,
RA Liang Y., Mason S., Paonessa P.D., Sauls A.D., DePalma G.E., Sharara R.,
RA Rowe L.B., Eppig J., Morrell C., Doi H.;
RT "Large-scale cDNA analysis reveals phased gene expression patterns during
RT preimplantation mouse development.";
RL Development 127:1737-1749(2000).
RN [5] {ECO:0000305, ECO:0000312|EMBL:DAA02003.1}
RP IDENTIFICATION, AND DEVELOPMENTAL STAGE.
RX PubMed=15083517; DOI=10.1002/gene.20015;
RA Good P.J., Abler L., Herring D., Sheets M.D.;
RT "Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new family
RT of cytoplasmic poly(A) binding proteins expressed during the early stages
RT of vertebrate development.";
RL Genesis 38:166-175(2004).
CC -!- FUNCTION: Binds the poly(A) tail of mRNA.
CC {ECO:0000250|UniProtKB:Q6TY21}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6TY21}.
CC -!- DEVELOPMENTAL STAGE: Expression is restricted to oogenesis, early
CC embryogenesis and the adult ovary. {ECO:0000269|PubMed:15083517}.
CC -!- SEQUENCE CAUTION:
CC Sequence=C85607; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=C85607; Type=Miscellaneous discrepancy; Note=Deletions and sequence errors.; Evidence={ECO:0000305};
CC Sequence=C85611; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=C85611; Type=Miscellaneous discrepancy; Note=Deletions and sequence errors.; Evidence={ECO:0000305};
CC Sequence=C86787; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=C86787; Type=Miscellaneous discrepancy; Note=Deletions and sequence errors.; Evidence={ECO:0000305};
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DR EMBL; BC141316; AAI41317.1; -; mRNA.
DR EMBL; BC141317; AAI41318.1; -; mRNA.
DR EMBL; BG080308; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BG067238; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CA556976; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BM225984; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; C85607; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; C85611; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; C86787; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK001615; DAA02003.1; -; mRNA.
DR CCDS; CCDS22743.1; -.
DR RefSeq; NP_001007463.1; NM_001007462.1.
DR AlphaFoldDB; Q5XFR0; -.
DR STRING; 10090.ENSMUSP00000090747; -.
DR iPTMnet; Q5XFR0; -.
DR PhosphoSitePlus; Q5XFR0; -.
DR MaxQB; Q5XFR0; -.
DR PaxDb; Q5XFR0; -.
DR PRIDE; Q5XFR0; -.
DR ProteomicsDB; 275929; -.
DR Antibodypedia; 50156; 61 antibodies from 12 providers.
DR DNASU; 382035; -.
DR Ensembl; ENSMUST00000093059; ENSMUSP00000090747; ENSMUSG00000069867.
DR GeneID; 382035; -.
DR KEGG; mmu:382035; -.
DR UCSC; uc009ntk.1; mouse.
DR CTD; 390748; -.
DR MGI; MGI:2685954; Pabpn1l.
DR VEuPathDB; HostDB:ENSMUSG00000069867; -.
DR eggNOG; KOG4209; Eukaryota.
DR GeneTree; ENSGT00940000161325; -.
DR HOGENOM; CLU_012062_23_2_1; -.
DR InParanoid; Q5XFR0; -.
DR OMA; MWPFLSH; -.
DR OrthoDB; 1412946at2759; -.
DR PhylomeDB; Q5XFR0; -.
DR TreeFam; TF105907; -.
DR BioGRID-ORCS; 382035; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Pabpn1l; mouse.
DR PRO; PR:Q5XFR0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q5XFR0; protein.
DR Bgee; ENSMUSG00000069867; Expressed in secondary oocyte and 13 other tissues.
DR ExpressionAtlas; Q5XFR0; baseline and differential.
DR Genevisible; Q5XFR0; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0008143; F:poly(A) binding; IDA:MGI.
DR GO; GO:0003723; F:RNA binding; IDA:MGI.
DR GO; GO:0160021; P:maternal-to-zygotic transition of gene expression; IMP:MGI.
DR GO; GO:0032091; P:negative regulation of protein binding; IDA:MGI.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IDA:MGI.
DR GO; GO:0062026; P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process; IDA:MGI.
DR GO; GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IMP:MGI.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; RNA-binding.
FT CHAIN 1..273
FT /note="Embryonic polyadenylate-binding protein 2"
FT /id="PRO_0000239462"
FT DOMAIN 143..220
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 22..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 59
FT /note="E -> V (in Ref. 3; CA556976)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 30263 MW; 1B54E6F01609EE5B CRC64;
MEPYLSNELF PPPTEAWLQT VSSDPEAQGW GAWGRTEKTS LVPRAGSRAG SDKEAEENED
ASFLLSLLEP ENLAKSPVFN QELEAIKLKL WAMEHAEAQP EPPCVQRKAT EEERAEVRQL
LSPETVDCFF SRTSKENVEA DHRSVFVGNV DYGGSAAELE AYFSPCGEIH RVTILCDKFS
GHPKGYAYIE FASHRSVKAA VGLDESTFRG RVIKVLPKRT NFPGISSTDR GGLRTHSGNR
AAFLHGSLHR KARLRAHGRS RGHGGAPQWF SPY
