EPAG_HUMAN
ID EPAG_HUMAN Reviewed; 149 AA.
AC Q14236;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Early lymphoid activation gene protein;
DE AltName: Full=DIAPH2 antisense RNA 1;
DE AltName: Full=DIAPH2 antisense gene protein 1;
GN Name=DIAPH2-AS1; Synonyms=EPAG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 41-149, FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Hematopoietic;
RX PubMed=8133036;
RA Bennett J.S., Tredway T.L., Dizikes G.J., Nawrocki J.F.;
RT "Properties of a novel gene isolated from a Hodgkin's disease cell line
RT that is expressed early during lymphoid cell activation.";
RL J. Immunol. 152:2229-2240(1994).
CC -!- FUNCTION: May function as an early signal that helps mediate the
CC activation of T-cells. {ECO:0000269|PubMed:8133036}.
CC -!- TISSUE SPECIFICITY: Expressed in heart, kidney, lung, and skeletal
CC muscle, with lower levels in pancreas and liver.
CC {ECO:0000269|PubMed:8133036}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA20152.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL391821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L22650; AAA20152.1; ALT_FRAME; mRNA.
DR PIR; I56219; I56219.
DR AlphaFoldDB; Q14236; -.
DR BioMuta; HGNC:16972; -.
DR MassIVE; Q14236; -.
DR PRIDE; Q14236; -.
DR GeneCards; DIAPH2-AS1; -.
DR HGNC; HGNC:16972; DIAPH2-AS1.
DR MIM; 300347; gene.
DR neXtProt; NX_Q14236; -.
DR InParanoid; Q14236; -.
DR ChiTaRS; DIAPH2-AS1; human.
DR Pharos; Q14236; Tdark.
DR PRO; PR:Q14236; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q14236; protein.
DR GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..149
FT /note="Early lymphoid activation gene protein"
FT /id="PRO_0000316949"
FT CONFLICT 145
FT /note="N -> K (in Ref. 2; AAA20152)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 149 AA; 17843 MW; 61071EB2CCC3B843 CRC64;
MNLYLHPKLW PQLAGTKTLH VADAQRVRKI TVHDGIWDAE LPRAKRNHSY HLRYHGSSYS
RCFLERYRCK TIGVFRRSNQ PDCLETRSEK AKNRDGVVQE KSVRTLFSEC VNQCDIRRRP
TRFLRMFYHQ KHFQLGLKGT ETEKNERRL
