ID   AGO15_ORYSJ             Reviewed;         889 AA.
AC   Q5NBN9; Q0JNP3;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein argonaute 15;
DE            Short=OsAGO15;
GN   Name=AGO15;
GN   OrderedLocusNames=Os01g0275200/Os01g0275300, LOC_Os01g16850/LOC_Os01g16860;
GN   ORFNames=P0038F12.10;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA   Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA   Kapoor S.;
RT   "Genome-wide identification, organization and phylogenetic analysis of
RT   dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT   their expression analysis during reproductive development and stress in
RT   rice.";
RL   BMC Genomics 9:451-451(2008).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC       short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC       (siRNAs), and represses the translation of mRNAs which are
CC       complementary to them (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD81109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAF04635.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP000836; BAD81109.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008207; BAF04635.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5NBN9; -.
DR   SMR; Q5NBN9; -.
DR   STRING; 4530.OS01T0275200-00; -.
DR   PaxDb; Q5NBN9; -.
DR   PRIDE; Q5NBN9; -.
DR   eggNOG; KOG1041; Eukaryota.
DR   InParanoid; Q5NBN9; -.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR   CDD; cd04657; Piwi_ago-like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032472; ArgoL2.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR045246; Piwi_ago-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16488; ArgoL2; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..889
FT                   /note="Protein argonaute 15"
FT                   /id="PRO_0000378438"
FT   DOMAIN          261..379
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          546..853
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          857..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   889 AA;  99524 MW;  88A00718BC067976 CRC64;
     MESHGDEGEP SAMAKPPKKL PMSRKGFGTR GQSIQLLTNH FRVSVRRMDG HFYHYHVEVK
     YEDGGPVEAK GVCRRVVDKL QETYASELAG REFAYNGEKG LFTAGALLQT KHQFVVVMED
     ASSSGRTTTR RSSGGDDGSP GGSDRKRMKR PMAVKKFMVE ISFAAKDPMS AIAEVLRGQE
     TENSMEALRV LDITLRQHSA KHARDTASCP SYPSAMDGWM KTGVPKGGRE KISCRGFHSS
     FRPTDSGLSL NVDVSTTMIV RPGPVIEFLL FNQNIKNPHE IDWGKAKCAL KNLRIKTTHT
     GSEFRIIGLS EDTCYSQTFQ IKRKNGNGGS DTVEEVTVFE YYRKNWKIDL KGSAHFPCLN
     VGKPKRPTYI PLELCHLVPL QRYKKALSTL QRSTLVERSR QNPQERMFVL SGVLRDSDYN
     SVPMLRECGI SIAQEFTQVA ARVLPAPKLK SGDGEDIFAR NGRWNFNKNR LIQPKRVQRW
     VVVNFSAQCN AHHLAQRLIH CGNLKGLPVD PEDHVFQERS HMGRERAETR VNDMFQQLLS
     GDKPSFVLCV LPERKNCDIY GPWKRMCLVK YGIVTQCLAP TKINDQYLTN VLLKINAKLG
     GLNSLLQIER NQAIPLLSKT PTIILGMDVS HGSPGRDDVP SVAAVVSSLE WPLISKYKAS
     VCTQSPRLEM IDSLFKLVGN EDHVIIRESL MDFYNSSRGH KDGVSEGQFN QVLNIELAQI
     IKACEFLANE KNDSEWSPKF TVIVAQKNHH TKFFQTDRSN KVVNVPPGTV VDKGICHPRN
     CDFYMCAHAG MIGTTRPTHY HVLHDENNFT PDDLQELVHN LSYVYQRSTT AISGVAPICY
     AHLAAAQVSQ FVRLDDAASE GSGDGGAPPR PVPELPRLHP DVRQSMFFC