ID   EPC2_XENLA              Reviewed;         804 AA.
AC   Q66JA8;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Enhancer of polycomb homolog 2;
GN   Name=epc2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in transcription or DNA repair.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the enhancer of polycomb family. {ECO:0000305}.
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DR   EMBL; BC080994; AAH80994.1; -; mRNA.
DR   RefSeq; NP_001087609.1; NM_001094140.1.
DR   AlphaFoldDB; Q66JA8; -.
DR   SMR; Q66JA8; -.
DR   BioGRID; 104293; 2.
DR   DNASU; 447433; -.
DR   GeneID; 447433; -.
DR   KEGG; xla:447433; -.
DR   CTD; 447433; -.
DR   Xenbase; XB-GENE-866062; epc2.S.
DR   OrthoDB; 957492at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 447433; Expressed in testis and 19 other tissues.
DR   GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR024943; Enhancer_polycomb.
DR   InterPro; IPR019542; Enhancer_polycomb-like_N.
DR   InterPro; IPR009607; Enhancer_polycomb_C.
DR   PANTHER; PTHR14898; PTHR14898; 1.
DR   Pfam; PF06752; E_Pc_C; 1.
DR   Pfam; PF10513; EPL1; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..804
FT                   /note="Enhancer of polycomb homolog 2"
FT                   /id="PRO_0000239297"
FT   REGION          372..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..669
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  90649 MW;  F4335E7A02CCEF7F CRC64;
     MSKLSFRARA LDATKPLPIF RGNDMPDLND CVSINRAVPQ MPTGMEKEEE SEHHLQRAIS
     AQQVFREKKE CMVIPVPEAE SNVHYYSRLY KGEFKQPKQF IHITPFNLDY EQPDYDMDSE
     DETLLNRLNR KMEIKPLQFE IMIDRLEKAS SNQLVSLQEA KLLLNEDDYL IKSVYDYWVR
     KRKNCRGPCL IPQVKQEKRD GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE
     FSRAITILEM IKRREKTKRE LLHLTLEVVE KRYNLGDFGG EILNEIKIPK ADKEIYAIPP
     SLHNGNHHKV PECKVKNTHH LNVKDEVLEI VRLKKKYPKK PKADILVTPL PQANSEPLAV
     INRSDIKQYD FQSSDDDEFP QVPSPLSELE EENDPDGSYA FRRRAGCQYY APHLDQMNDT
     PETTDLSGLA RHRNRHCLTT LTVPRRCIGF ARKRLGRGGR VIMDRLSTEH DSVLKQIDPE
     MLSGFSSSSH IAQPPSSPSR TNASDRHCEN RLSLPEILSN IKSCRLQCFQ PRLLHTQDSD
     REECTSRLGQ AVNLKRVSSS LLNTSKNGIT VTGGITEEQF QTHQQQLVQM QKQQLAQLQQ
     KQQSQQSLQQ SHPKAQGSGS SDCMSKTLDS ASALFAASAV VNSPAPVRSE VNKDQNAGHS
     NLNGVVQPSG TAKTLYSTNM ALSSSPGIST VQLVRTVGHP TTNHLIPTLC TSNPQTLTMG
     NSCLANTVHL NNVSVVSPVN VHLNTRTSAP SPTALKLATV AASMDRVPKV TPSSAMSSIA
     RENHEPERLG LNGITDTTVA MEVT