ID   EPC2_XENTR              Reviewed;         804 AA.
AC   Q6DJR9;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Enhancer of polycomb homolog 2;
GN   Name=epc2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in transcription or DNA repair.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the enhancer of polycomb family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC075105; AAH75105.1; -; mRNA.
DR   RefSeq; NP_001005683.1; NM_001005683.1.
DR   AlphaFoldDB; Q6DJR9; -.
DR   SMR; Q6DJR9; -.
DR   STRING; 8364.ENSXETP00000041789; -.
DR   PaxDb; Q6DJR9; -.
DR   PRIDE; Q6DJR9; -.
DR   DNASU; 448185; -.
DR   GeneID; 448185; -.
DR   KEGG; xtr:448185; -.
DR   CTD; 26122; -.
DR   Xenbase; XB-GENE-491423; epc2.
DR   eggNOG; KOG2261; Eukaryota.
DR   InParanoid; Q6DJR9; -.
DR   OrthoDB; 957492at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR024943; Enhancer_polycomb.
DR   InterPro; IPR019542; Enhancer_polycomb-like_N.
DR   InterPro; IPR009607; Enhancer_polycomb_C.
DR   PANTHER; PTHR14898; PTHR14898; 1.
DR   Pfam; PF06752; E_Pc_C; 1.
DR   Pfam; PF10513; EPL1; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..804
FT                   /note="Enhancer of polycomb homolog 2"
FT                   /id="PRO_0000239298"
FT   REGION          372..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          642..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  90738 MW;  FB320113258FAC2E CRC64;
     MSKLSFRARA LDAAKPLPIY RGKDMPDLND CVSINRAVPQ MPTGMEKEEE SEHHLQRAIS
     AQQVFREKKE SMVIPVPEAE SNVHYYSRLY KGEFKQPKQF IHIQPFNLDY EQPDYDMDSE
     DETLLNRLNR KMEIKPLQFE IMIDRLEKAS SNQLVTLQEA KLLLNEDDYL IKSVYDYWVR
     KRKNCRGPSL IPQVKQEKRD GSTNNDPYVA FRRRTEKMQT RKNRKNDEVS YEKMLKLRRE
     FSRAITILEM IKRREKTKRE LLHLTLEVVE KRYNLGDFGG EILNEIKIPK VEKEIHVIPP
     SLHNGNHHKV PECKVKNTHH PSVKDEVLEI VRLKKKYPKK PKAETLVTPQ PQATSEPLAV
     INKSDIKQYD FQSSDDDEFP QVPSPLSELE EENDPDGSYA FRRRTGCQYY APRLDQMNDT
     PETTDLSGLA RHRYRHCLTT LTVPRRCIGF ARKRLGRGGR VIMDRLSTEH DSILKQIDPE
     MLSGFSSSSH VAQPPSSPSR TNASDRHCEN RLSLPEILSN IKSCRLQCFQ PRLLHTQDSD
     REECTSRLGQ AVNVKRVSAA LLNTSKNGIT VTGGITEEQF QTHQQQLVQM QRQQLAQLQQ
     KQQSQQSLQQ SHPKAQGSAK SDCMSKTLDS ASALFAASAV VNSPTPGRSE VNKDQNAGHS
     NLNGVVQPSG TAKTLYSTNM ALSSSPGIST VQLVRTVGHP TTNHLIPTLC TSNPQTLTMG
     NSCLANTVHL NNVSVVSPVN VHINTRTSAP SPTALKLATV AASMDRVPKV TPSSAISSIA
     RENHEPERLG LNGIADTTVA MEVT