ID   AGO16_ORYSJ             Reviewed;         883 AA.
AC   Q6YSJ5; Q0D7C4; Q7XBH5; Q8S9N1;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein argonaute 16;
DE            Short=OsAGO16;
DE   AltName: Full=OsAGO6;
DE   AltName: Full=Protein ZWILLE/PINHEAD-like 1;
GN   Name=AGO16; Synonyms=ZP1; OrderedLocusNames=Os07g0265600, LOC_Os07g16224;
GN   ORFNames=B1059D01.1, B1100H02.17;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 517-883.
RA   Quanhong Y., Rihe P., Aisheng X.;
RT   "A rice zwille pinhead-like protein takes part in disease resistant through
RT   H-box.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-883.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 693-883.
RA   Rihe P., Quanhong Y., Aisheng X., Xian L., Huiqin F.;
RT   "Oryza sativa zwille/pinhead-like protein mRNA.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA   Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA   Kapoor S.;
RT   "Genome-wide identification, organization and phylogenetic analysis of
RT   dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT   their expression analysis during reproductive development and stress in
RT   rice.";
RL   BMC Genomics 9:451-451(2008).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC       short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC       (siRNAs), and represses the translation of mRNAs which are
CC       complementary to them (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL77199.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAL77199.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC       Sequence=AAP92749.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP92749.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAC84805.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAD32046.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAF21249.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006447; BAC84805.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP006465; BAD32046.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008213; BAF21249.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY323483; AAP92749.1; ALT_SEQ; mRNA.
DR   EMBL; AK101842; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AY072819; AAL77199.1; ALT_SEQ; mRNA.
DR   AlphaFoldDB; Q6YSJ5; -.
DR   SMR; Q6YSJ5; -.
DR   STRING; 4530.OS07T0265600-01; -.
DR   PaxDb; Q6YSJ5; -.
DR   PRIDE; Q6YSJ5; -.
DR   eggNOG; KOG1041; Eukaryota.
DR   InParanoid; Q6YSJ5; -.
DR   Proteomes; UP000000763; Chromosome 7.
DR   Proteomes; UP000059680; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR   CDD; cd04657; Piwi_ago-like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032472; ArgoL2.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR045246; Piwi_ago-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16488; ArgoL2; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..883
FT                   /note="Protein argonaute 16"
FT                   /id="PRO_0000378439"
FT   DOMAIN          253..366
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          535..844
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   CONFLICT        636
FT                   /note="V -> A (in Ref. 4; AAP92749)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   883 AA;  98762 MW;  4C83F742DB2CCEAD CRC64;
     MAAKIGEIVQ VHNDNPVKRV PIARPSFGRE GKQIKLLSNH FTVKLSGIDA VFYQYSVSIK
     SEDDKVIDGK GIGRKVMDKV LQTYSSELAG KEFAYDGEKC LFTVGPLPQN NFEFTVILEE
     TSSRAAGGSL GHGSPNQGDK KRSKCTHLAK KIVVGISYAA KIPLKSVALA LQGSESDHAQ
     DALRVLDIVL RQQQAKRGCL LVRQSFFSDD FRNLVDLTGG VSGCRGLHSS FRTTIGGLSL
     NMDVSTTMIV TPGPVFDFLL TNQNVRDIRD IDWPRAKKML KNLRVKAIHN NMEFKIIGLS
     DEPCSRQTFP MKVRNGSSEG ETVEITVQEY FKSKQVDLTM PYLPCLDVGK PKRPNYVPIE
     LCHMVSLQRY TKALSSQQRA TLVEKSRQKP QERMRVVTDA VKNNRYDDDP ILSSCGIKIE
     KQLTRVDGRV LSAPTLVVGN SEDCIPNRGR WNYNNKRLFE PVKIERWAIV NFSARCDMSR
     ISRDLINCGR TKGIIIERPF TLVDEDSQSR RCTPVVRVES MFEKVKANLP GPPEFLLCVL
     PERKNCDLYG PWKKKNLHEM GIITQCIVPS VKMNDQYYTN VLLKINAKLG GMNSKLSLEH
     RHMIPIVNQT PTLILGMDVS HGSPGRADVP SIAAVVGSRC WPLISRYRAS VRTQSPKVEM
     IDSLFKPLDD GKDDGIIREL LLDFYKTSQQ RKPKQIIIFR DGVSESQFSQ VLNVELNQII
     KAYQYMDQGP IPKFTVIIAQ KNHHTKLFQE NTPDNVPPGT VVDSGIVHPR QYDFYMYAHA
     GPIGTSRPTH YHVLLDEIGF LPDDVQKLVL SLSYVYQRST TAISVVAPIC YAHLAAAQMG
     QFMKFEEFAE TSSGSGGVPS SSGAVVPELP RLHADVCSSM FFC