ID   EPCAM_CHICK             Reviewed;         306 AA.
AC   Q5F381;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Epithelial cell adhesion molecule;
DE            Short=Ep-CAM;
DE   AltName: Full=Tumor-associated calcium signal transducer 1;
DE   Flags: Precursor;
GN   Name=EPCAM; Synonyms=TACSTD1; ORFNames=RCJMB04_29h4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Lateral cell membrane
CC       {ECO:0000250|UniProtKB:P16422}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:P16422}.
CC   -!- SIMILARITY: Belongs to the EPCAM family. {ECO:0000305}.
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DR   EMBL; AJ851769; CAH65403.1; -; mRNA.
DR   RefSeq; NP_001012582.1; NM_001012564.1.
DR   AlphaFoldDB; Q5F381; -.
DR   SMR; Q5F381; -.
DR   STRING; 9031.ENSGALP00000014571; -.
DR   PaxDb; Q5F381; -.
DR   GeneID; 421292; -.
DR   KEGG; gga:421292; -.
DR   CTD; 4072; -.
DR   VEuPathDB; HostDB:geneid_421292; -.
DR   eggNOG; ENOG502QVSU; Eukaryota.
DR   InParanoid; Q5F381; -.
DR   OrthoDB; 1017141at2759; -.
DR   PhylomeDB; Q5F381; -.
DR   PRO; PR:Q5F381; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098641; F:cadherin binding involved in cell-cell adhesion; IBA:GO_Central.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.800.10; -; 1.
DR   InterPro; IPR043406; EPCAM/Trop-2.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR14168; PTHR14168; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF57610; SSF57610; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..306
FT                   /note="Epithelial cell adhesion molecule"
FT                   /id="PRO_0000380186"
FT   TOPO_DOM        20..260
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..306
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          58..130
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        61..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
FT   DISULFID        105..110
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
FT   DISULFID        112..130
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
SQ   SEQUENCE   306 AA;  34360 MW;  BDC7C9769267D900 CRC64;
     MELLRGAALL LLLCAAACAQ DSCTCTKNKR VTNCRLIDNV CHCNSIGSSV PVNCEILTSK
     CLLMKAEMAN TKSGRREKPK DALQDTDGLY DPECENNGLF KAKQCNGTTC WCVNTAGVRR
     TDKHDTDLKC NQLVRTTWII IEMRHAERKT PLNAESLTRY LKDTITSRYM LDGRYISGVV
     YENPTITIDL KQNSSDKTPG DVDITDVAYY FEKDVKDDSI FLNNKLNMNI DNEELKFDNM
     MVYYVDEVPP EFSMKSLTAG VIAVIVIVVL AIVAGIIGLV LSRRRKGKYV KAEMKEMNEM
     HRGLNA