ID   EPCR_RAT                Reviewed;         241 AA.
AC   Q4V8I1;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Endothelial protein C receptor;
DE   AltName: Full=Activated protein C receptor;
DE            Short=APC receptor;
DE   AltName: Full=Endothelial cell protein C receptor;
DE   AltName: CD_antigen=CD201;
DE   Flags: Precursor;
GN   Name=Procr;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Binds activated protein C. Enhances protein C activation by
CC       the thrombin-thrombomodulin complex; plays a role in the protein C
CC       pathway controlling blood coagulation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   EMBL; BC097380; AAH97380.1; -; mRNA.
DR   EMBL; BC099115; AAH99115.1; -; mRNA.
DR   RefSeq; NP_001020904.1; NM_001025733.2.
DR   AlphaFoldDB; Q4V8I1; -.
DR   SMR; Q4V8I1; -.
DR   STRING; 10116.ENSRNOP00000052129; -.
DR   GlyGen; Q4V8I1; 5 sites.
DR   PaxDb; Q4V8I1; -.
DR   PRIDE; Q4V8I1; -.
DR   Ensembl; ENSRNOT00000055254; ENSRNOP00000052129; ENSRNOG00000019330.
DR   GeneID; 362248; -.
DR   KEGG; rno:362248; -.
DR   UCSC; RGD:1305991; rat.
DR   CTD; 10544; -.
DR   RGD; 1305991; Procr.
DR   eggNOG; ENOG502S3SK; Eukaryota.
DR   GeneTree; ENSGT00390000001159; -.
DR   HOGENOM; CLU_1151498_0_0_1; -.
DR   InParanoid; Q4V8I1; -.
DR   OMA; QDPESWA; -.
DR   OrthoDB; 1203534at2759; -.
DR   PhylomeDB; Q4V8I1; -.
DR   Reactome; R-RNO-140875; Common Pathway of Fibrin Clot Formation.
DR   Reactome; R-RNO-202733; Cell surface interactions at the vascular wall.
DR   PRO; PR:Q4V8I1; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000019330; Expressed in ovary and 19 other tissues.
DR   Genevisible; Q4V8I1; RN.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0050819; P:negative regulation of coagulation; ISO:RGD.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR015669; Endothetial_C_recpt.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   PANTHER; PTHR15349; PTHR15349; 1.
DR   Pfam; PF16497; MHC_I_3; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
PE   2: Evidence at transcript level;
KW   Blood coagulation; Glycoprotein; Hemostasis; Membrane; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..241
FT                   /note="Endothelial protein C receptor"
FT                   /id="PRO_0000021193"
FT   TOPO_DOM        21..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   241 AA;  26839 MW;  855D39A3DE5CD6BF CRC64;
     MLTKFLSLLL LLLLLGCAFC NSDGSQSLHM LQISYFPDPY HGRHQGNASL GKLLTHTLEG
     PSNNVTILQL QDWQDPDSWA RTESGLKIYL SQFNSLVQLI YRERKNDVVF PLTVSCSVGC
     ELPPEEGSEP HVFFDVAVNG SAFVSFQPKT AIWVTGSQEP SEAINFTLKQ LNTYNRTRYE
     LQEFLQDTCV QYLENHITTQ NTKGSQTGRS YTSLVLGILM GCFIIAGVAV GIFLCTGGRR
     C