AGO18_ORYSJ
ID AGO18_ORYSJ Reviewed; 1088 AA.
AC Q69UP6; Q0D6K0;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein argonaute 18;
DE Short=OsAGO18;
GN Name=AGO18; OrderedLocusNames=Os07g0471300, LOC_Os07g28850;
GN ORFNames=OJ1103_E04.115, P0675B10.105;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 346-1088.
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA Kapoor S.;
RT "Genome-wide identification, organization and phylogenetic analysis of
RT dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT their expression analysis during reproductive development and stress in
RT rice.";
RL BMC Genomics 9:451-451(2008).
CC -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC (siRNAs), and represses the translation of mRNAs which are
CC complementary to them (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK069685; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAF21523.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP003806; BAD30270.1; -; Genomic_DNA.
DR EMBL; AP004347; BAD30662.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF21523.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK069685; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015644916.1; XM_015789430.1.
DR AlphaFoldDB; Q69UP6; -.
DR SMR; Q69UP6; -.
DR STRING; 4530.OS07T0471300-01; -.
DR PaxDb; Q69UP6; -.
DR PRIDE; Q69UP6; -.
DR GeneID; 4343201; -.
DR KEGG; osa:4343201; -.
DR eggNOG; KOG1041; Eukaryota.
DR HOGENOM; CLU_004544_4_3_1; -.
DR InParanoid; Q69UP6; -.
DR OrthoDB; 159407at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR Genevisible; Q69UP6; OS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR CDD; cd04657; Piwi_ago-like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR014811; ArgoL1.
DR InterPro; IPR032472; ArgoL2.
DR InterPro; IPR032473; Argonaute_Mid_dom.
DR InterPro; IPR032474; Argonaute_N.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR045246; Piwi_ago-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF08699; ArgoL1; 1.
DR Pfam; PF16488; ArgoL2; 1.
DR Pfam; PF16487; ArgoMid; 1.
DR Pfam; PF16486; ArgoN; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM01163; DUF1785; 1.
DR SMART; SM00949; PAZ; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; SSF101690; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; RNA-mediated gene silencing.
FT CHAIN 1..1088
FT /note="Protein argonaute 18"
FT /id="PRO_0000378441"
FT DOMAIN 458..574
FT /note="PAZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT DOMAIN 747..1056
FT /note="Piwi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT REGION 1..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 511
FT /note="R -> S (in Ref. 4; AK069685)"
FT /evidence="ECO:0000305"
FT CONFLICT 587
FT /note="V -> A (in Ref. 4; AK069685)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1088 AA; 118035 MW; F18920070EE050CA CRC64;
MASRGGGQHQ RHQQQQQQPG GYGRGGGGGR GRGRDGAPYS GGRGRGQDGS YPGGRGGGYG
GGGGGGGPPY YGGGGGGGGG GGGQGRGYYD DGGDGRGYQR GMEGGGGRGG YRGDGDGGYG
RGGGGYHGDG ERGYGRGGGG GGGGGGGYRG DDEGRSSYGR ARGGGGGGGG YHGDGEAGYG
RGRGGRDYDG GRGGGGRRGG RGGGGSSYHQ QPPPDLPQAP EPRLAAQYAR EIDIAALRAQ
FKGLTTTTPG AASSQFPARP GFGAAGEECL VKVNHFFVGL KNDNFHHYDV AIAPDPVLKG
LFRTIISKLV TERRHTDFGG RLPVYDGRAN LYTAGELPFR SRELEVELSG SRKFKVAIRH
VAPVSLQDLR MVMAGCPAGI PSQALQLLDI VLRDMVLAER NDMGYVAFGR SYFSPGLGSR
ELDKGIFAWK GFYQSCRVTQ QGLSLNIDMS STAFIEPGRV LNFVEKAIGR RITNAITVGY
FLNNYGNELM RTLKGVKVEV THRGNLRKKY RIAGFTEQSA DVQTFTSSDG IKTVKEYFNK
KYNLKLAFGY LPCLQVGSKE RPNYLPMELC NIVPGQRYKN RLSPTQVSNL INITNDRPCD
RESSIRQTVS SNQYNSTERA DEFGIEVDSY PTTLKARVLK APMLKYHDSG RVRVCTPEDG
AWNMKDKKVV NGATIKSWAC VNLCEGLDNR VVEAFCLQLV RTSKITGLDF ANVSLPILKA
DPHNVKTDLP MRYQEACSWS RDNKIDLLLV VMTDDKNNAS LYGDVKRICE TEIGVLSQCC
RAKQVYKERN VQYCANVALK INAKAGGRNS VFLNVEASLP VVSKSPTIIF GADVTHPGSF
DESTPSIASV VASADWPEVT KYNSVVRMQA SRKEIIQDLD SIVRELLNAF KRDSKMEPKQ
LIFYRDGVSE GQFQQVVESE IPEIEKAWKS LYAGKPRITF IVVQKRHHTR LFPNNYNDPR
GMDGTGNVRP GTVVDTVICH PREFDFFLCS QAGIKGTSRP SHYHVLRDDN NFTADQLQSV
TNNLCYLYTS CTRSVSIPPP VYYAHKLAFR ARFYLTQVPV AGGDPGAAKF QWVLPEIKEE
VKKSMFFC
