EPDR1_MACFA
ID EPDR1_MACFA Reviewed; 224 AA.
AC Q9N0C7; Q95K54; Q95K77;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 3.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Mammalian ependymin-related protein 1;
DE Short=MERP-1;
DE Flags: Precursor;
GN Name=EPDR1; Synonyms=MERP1;
GN ORFNames=QccE-12983, QmoA-12340, QmoA-13475, QtrA-11871;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex, Medulla oblongata, and Temporal cortex;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Medulla oblongata;
RX PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT chromosomes.";
RL Gene 275:31-37(2001).
CC -!- FUNCTION: Binds anionic lipids and gangliosides at acidic pH.
CC {ECO:0000250|UniProtKB:Q9UM22}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9UM22}.
CC -!- SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000250|UniProtKB:Q9UM22}.
CC Secreted {ECO:0000250|UniProtKB:Q9UM22}. Note=Lysosomal and also
CC secreted. {ECO:0000250|UniProtKB:Q9UM22}.
CC -!- PTM: N-glycosylated; the glycan contains mannose-6-phosphate moieties.
CC {ECO:0000250|UniProtKB:Q99M71}.
CC -!- SIMILARITY: Belongs to the ependymin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB01585.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB60800.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB62213.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC41745.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB046003; BAB01585.1; ALT_INIT; mRNA.
DR EMBL; AB063094; BAB60800.1; ALT_INIT; mRNA.
DR EMBL; AB066537; BAB62213.1; ALT_INIT; mRNA.
DR EMBL; AB097520; BAC41745.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q9N0C7; -.
DR SMR; Q9N0C7; -.
DR STRING; 9541.XP_005549818.1; -.
DR eggNOG; ENOG502QQ8T; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR InterPro; IPR001299; Ependymin.
DR InterPro; IPR018224; Ependymin_CS.
DR PANTHER; PTHR10697; PTHR10697; 1.
DR Pfam; PF00811; Ependymin; 1.
DR PRINTS; PR00317; EPENDYMIN.
DR SMART; SM00026; EPEND; 1.
DR PROSITE; PS00898; EPENDYMIN_1; 1.
DR PROSITE; PS00899; EPENDYMIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Lipid-binding; Lysosome; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000255"
FT CHAIN 38..224
FT /note="Mammalian ependymin-related protein 1"
FT /id="PRO_0000008352"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 42..172
FT /evidence="ECO:0000250|UniProtKB:Q9UM22"
FT DISULFID 88..222
FT /evidence="ECO:0000250|UniProtKB:Q9UM22"
FT DISULFID 113..210
FT /evidence="ECO:0000250|UniProtKB:Q9UM22"
FT CONFLICT 47
FT /note="Q -> L (in Ref. 1; BAB60800 and 2; BAC41745)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="V -> L (in Ref. 1; BAB62213)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="F -> V (in Ref. 1; BAB01585)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 224 AA; 25532 MW; 358E80B615AB4BB7 CRC64;
MPGRAPLHTV PGALGPWLLG CLWAWTLCGL CSLGAVGAPR PCQAPQQWEG RQVMYQQSSG
RNSRALLSYD GLNQRVRVLD ERKALIPCKR LFEYILLYKD GVMFQIEQAT KQCSKMTLTE
PWDPLDIPQN STFEDQYSIG GPQEQIMVQE WSDRKSARSY ETWIGIYTVK DCYPVQETFT
KNYSVILSTR FFDIQLGIKD PSVFTPPSTC QIAQLEKMSE DCSW
