ID   EPD_CYPCA               Reviewed;         215 AA.
AC   P38528;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Ependymin;
DE            Short=EPD;
DE   Flags: Precursor;
GN   Name=epd; Synonyms=epn;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Brain;
RX   PubMed=8163195; DOI=10.1016/0378-1119(94)90578-9;
RA   Adams D.S., Shashoua V.E.;
RT   "Cloning and sequencing the genes encoding goldfish and carp ependymin.";
RL   Gene 141:237-241(1994).
CC   -!- FUNCTION: May play a role in neural plasticity. May be involved during
CC       axon regeneration.
CC   -!- SUBUNIT: Forms disulfide-linked dimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: EPDs are synthesized in the meninx and secreted in
CC       the cerebrospinal fluid.
CC   -!- PTM: Binds calcium through the terminal sialic acids.
CC   -!- SIMILARITY: Belongs to the ependymin family. {ECO:0000305}.
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DR   EMBL; U00432; AAA19565.1; -; Genomic_DNA.
DR   PIR; I51377; I51377.
DR   AlphaFoldDB; P38528; -.
DR   SMR; P38528; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   InterPro; IPR001299; Ependymin.
DR   InterPro; IPR018224; Ependymin_CS.
DR   PANTHER; PTHR10697; PTHR10697; 1.
DR   Pfam; PF00811; Ependymin; 1.
DR   PRINTS; PR00317; EPENDYMIN.
DR   SMART; SM00026; EPEND; 1.
DR   PROSITE; PS00898; EPENDYMIN_1; 1.
DR   PROSITE; PS00899; EPENDYMIN_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..215
FT                   /note="Ependymin"
FT                   /id="PRO_0000008344"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   215 AA;  23992 MW;  37007AB6ABDBCBBE CRC64;
     MHTVKLLCVV FSCLCAVAWA SSNRQPCHSP PLTSGTMKVV STGGHDLASG EFSYDSKANK
     FRFVEDTAHA NKTSHMDVLV HFEEGVLYEI DSKNESCKKE TLQFRKHLME IPPDATHESE
     IYMGSPSITE QGLRVRVWNG KLPELHAHYS LSTTSCGCLP VSGSYYGDKK DLLFSFFGVE
     TEVDDPQVFV PPAYCEAVAF EEAPDDHSFF DLFHD