ID   EPD_DANRE               Reviewed;         217 AA.
AC   P17561; Q561Y9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Ependymin;
DE            Short=EPD;
DE   Flags: Precursor;
GN   Name=epd;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=2243597; DOI=10.1016/0306-4522(90)90214-o;
RA   Sterrer S., Koenigstorfer A., Hoffmann W.;
RT   "Biosynthesis and expression of ependymin homologous sequences in zebrafish
RT   brain.";
RL   Neuroscience 37:277-284(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1524676; DOI=10.1089/dna.1992.11.425;
RA   Rinder H., Bayer T.A., Gertzen E., Hoffmann W.;
RT   "Molecular analysis of the ependymin gene and functional test of its
RT   promoter region by transient expression in Brachydanio rerio.";
RL   DNA Cell Biol. 11:425-432(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in neural plasticity. May be involved during
CC       axon regeneration.
CC   -!- SUBUNIT: Forms disulfide-linked dimers.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: EPDs are synthesized in the meninx and secreted in
CC       the cerebrospinal fluid.
CC   -!- PTM: Binds calcium through the terminal sialic acids.
CC   -!- SIMILARITY: Belongs to the ependymin family. {ECO:0000305}.
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DR   EMBL; X52502; CAA36742.1; -; mRNA.
DR   EMBL; M89643; AAA50026.1; -; Genomic_DNA.
DR   EMBL; BC092712; AAH92712.1; -; mRNA.
DR   PIR; A43820; A43820.
DR   RefSeq; NP_571080.1; NM_131005.2.
DR   AlphaFoldDB; P17561; -.
DR   SMR; P17561; -.
DR   STRING; 7955.ENSDARP00000049894; -.
DR   PaxDb; P17561; -.
DR   Ensembl; ENSDART00000171617; ENSDARP00000134034; ENSDARG00000103498.
DR   GeneID; 30199; -.
DR   KEGG; dre:30199; -.
DR   CTD; 30199; -.
DR   ZFIN; ZDB-GENE-980526-111; epd.
DR   eggNOG; ENOG502S4KH; Eukaryota.
DR   GeneTree; ENSGT00940000168284; -.
DR   HOGENOM; CLU_097673_1_0_1; -.
DR   InParanoid; P17561; -.
DR   OMA; MSVTMGC; -.
DR   OrthoDB; 1284695at2759; -.
DR   PhylomeDB; P17561; -.
DR   PRO; PR:P17561; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000103498; Expressed in brain and 12 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   InterPro; IPR001299; Ependymin.
DR   InterPro; IPR018224; Ependymin_CS.
DR   PANTHER; PTHR10697; PTHR10697; 1.
DR   Pfam; PF00811; Ependymin; 1.
DR   PRINTS; PR00317; EPENDYMIN.
DR   SMART; SM00026; EPEND; 1.
DR   PROSITE; PS00898; EPENDYMIN_1; 1.
DR   PROSITE; PS00899; EPENDYMIN_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT   CHAIN           21..217
FT                   /note="Ependymin"
FT                   /id="PRO_0000008340"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        78
FT                   /note="M -> I (in Ref. 1; CAA36742)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   217 AA;  24472 MW;  3EED80F2A39FFA43 CRC64;
     MHTVKLLCVV FSCLCAIGWA SHHSHRQPCH SPQLTSGTMK VVSTGGHDLA SGEFSYDSKT
     NKFRFVEDTT HANKTSYMDV LIHFEEGVLY EIDSKNESCK KETLQFRKHL MEIPVDATHE
     SESYMGSPSL TEQGLRVRVW NGKFPELHAH YSLSTTSCGC LTVSGSYYGE KKDLFFSFFG
     VETEVDDLQV FAPPAYCEGV SFEEAPDDHS FFDLFHD