ID   EPD_DEVAE               Reviewed;         218 AA.
AC   Q90399;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Ependymin;
DE            Short=EPD;
DE   Flags: Precursor;
GN   Name=epd;
OS   Devario aequipinnatus (Giant danio) (Danio aequipinnatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Devario.
OX   NCBI_TaxID=46778;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Brain;
RX   PubMed=9139245; DOI=10.1007/bf02531655;
RA   Adams D.S., Kiyokawa M., Getman M.E., Shashoua V.E.;
RT   "Genes encoding giant danio and golden shiner ependymin.";
RL   Neurochem. Res. 21:377-384(1996).
CC   -!- FUNCTION: May play a role in neural plasticity. May be involved during
CC       axon regeneration (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms disulfide-linked dimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Binds calcium through the terminal sialic acids. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ependymin family. {ECO:0000305}.
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DR   EMBL; U31356; AAC59752.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q90399; -.
DR   SMR; Q90399; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   InterPro; IPR001299; Ependymin.
DR   InterPro; IPR018224; Ependymin_CS.
DR   PANTHER; PTHR10697; PTHR10697; 1.
DR   Pfam; PF00811; Ependymin; 1.
DR   PRINTS; PR00317; EPENDYMIN.
DR   SMART; SM00026; EPEND; 1.
DR   PROSITE; PS00898; EPENDYMIN_1; 1.
DR   PROSITE; PS00899; EPENDYMIN_2; 1.
PE   3: Inferred from homology;
KW   Calcium; Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..218
FT                   /note="Ependymin"
FT                   /id="PRO_0000008345"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  24479 MW;  8D0873B9000E0AC8 CRC64;
     MHTVKLLCVV FSCLCAVAWG SSHVSNRQPC HSPQLTSGTM KVISTGGHDL ASGEFNYDSK
     ANKFRFVEDT THANKTSYMD VLVHFEEGVL YEIDSKNESC KKETLQFRKH LMEIPPDATH
     ESEIYMGSPS ITEQGLRVRV WNGKLPELHA HYSLSTTSCG CLPVSGSYYG EKKDLFFSFF
     GVETEVDDPQ VFVPPAYCEG VSFEEAPDDH SFFDLFHD