ID   AGO1A_ORYSJ             Reviewed;        1082 AA.
AC   Q6EU14; A0A0N7KFV1;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Protein argonaute 1A;
DE            Short=OsAGO1a;
GN   Name=AGO1A; OrderedLocusNames=Os02g0672200, LOC_Os02g45070;
GN   ORFNames=OJ1493_H11.13;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA   Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA   Kapoor S.;
RT   "Genome-wide identification, organization and phylogenetic analysis of
RT   dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT   their expression analysis during reproductive development and stress in
RT   rice.";
RL   BMC Genomics 9:451-451(2008).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC       short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC       (siRNAs), and represses the translation of mRNAs which are
CC       complementary to them (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK111553; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AP004188; BAD27856.1; -; Genomic_DNA.
DR   EMBL; AP008208; BAF09618.1; -; Genomic_DNA.
DR   EMBL; AP014958; BAS80241.1; -; Genomic_DNA.
DR   EMBL; AK111553; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015626096.1; XM_015770610.1.
DR   AlphaFoldDB; Q6EU14; -.
DR   SMR; Q6EU14; -.
DR   STRING; 4530.OS02T0672200-01; -.
DR   PaxDb; Q6EU14; -.
DR   PRIDE; Q6EU14; -.
DR   EnsemblPlants; Os02t0672200-01; Os02t0672200-01; Os02g0672200.
DR   GeneID; 4330281; -.
DR   Gramene; Os02t0672200-01; Os02t0672200-01; Os02g0672200.
DR   KEGG; osa:4330281; -.
DR   eggNOG; KOG1041; Eukaryota.
DR   HOGENOM; CLU_004544_0_0_1; -.
DR   InParanoid; Q6EU14; -.
DR   OMA; FPIDNHG; -.
DR   OrthoDB; 159407at2759; -.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   ExpressionAtlas; Q6EU14; baseline and differential.
DR   Genevisible; Q6EU14; OS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR   CDD; cd04657; Piwi_ago-like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032472; ArgoL2.
DR   InterPro; IPR024357; Argonaut_Gly-rich.
DR   InterPro; IPR032473; Argonaute_Mid_dom.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR045246; Piwi_ago-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16488; ArgoL2; 1.
DR   Pfam; PF16487; ArgoMid; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF12764; Gly-rich_Ago1; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..1082
FT                   /note="Protein argonaute 1A"
FT                   /id="PRO_0000378425"
FT   DOMAIN          419..533
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          709..1030
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   REGION          17..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1036..1065
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        163
FT                   /note="G -> A (in Ref. 4; AK111553)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        280
FT                   /note="K -> E (in Ref. 4; AK111553)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1082 AA;  120449 MW;  FAE0E9368D02B91D CRC64;
     MAFQLDNGYY SHQALAMMRK KKTEPRNAGE SSGTQQATGA PGRGPSQRPE RAQQHGGGGW
     QPANPQYAQQ AGRGGGQHQG RGGRYQGRGG PTSHQPGGGP VEYQAHEYYG RGVQRQGGMP
     QHRSGSGGHG VPASPSRTVP ELHQASQDQY QATVVAPSPS RTGPSSLPVE ASSEEVQHQF
     QELAIQGQSP TSQAIQPAPP SSKSVRFPMR PGKGTFGDRC IVKANHFFAE LPDKDLHQYD
     VSITPEVPSR GVNRAVIGEI VTQYRQSHLG GRLPVYDGRK SLYTAGPLPF TSRTFDVILQ
     DEEESLAVGQ GAQRRERPFK VVIKFAARAD LHHLAMFLAG RQADAPQEAL QVLDIVLREL
     PTARYSPVAR SFYSPNLGRR QQLGEGLESW RGFYQSIRPT QMGLSLNIDM SSTAFIEPLP
     VIDFVAQLLN RDISVRPLSD ADRVKIKKAL RGVKVEVTHR GNMRRKYRIS GLTSQATREL
     SFPIDNHGTV KTVVQYFQET YGFNIKHTTL PCLQVGNQQR PNYLPMEVCK IVEGQRYSKR
     LNEKQITALL KVTCQRPQER ELDILQTVHH NAYHQDPYAQ EFGIRIDERL ASVEARVLPP
     PWLKYHDSGR EKDVLPRIGQ WNMMNKKMVN GGRVNNWTCI NFSRHVQDNA ARSFCRELAI
     MCQISGMDFS IDPVVPLVTA RPEHVERALK ARYQEAMNIL KPQGGELDLL IAILPDNNGS
     LYGDLKRICE TDLGLVSQCC LTKHVFKMSK QYLANVALKI NVKVGGRNTV LVDALTRRIP
     LVSDRPTIIF GADVTHPHPG EDSSPSIAAV VASQDWPEVT KYAGLVSAQA HRQELIQDLF
     KVWKDPQRGT VSGGMIRELL ISFKRATGQK PQRIIFYRDG VSEGQFYQVL FYELDAIRKA
     CASLEADYQP PVTFVVVQKR HHTRLFANNH KDQRTVDRSG NILPGTVVDS KICHPTEFDF
     YLCSHAGIQG TSRPAHYHVL WDENKFTADG LQTLTNNLCY TYARCTRSVS IVPPAYYAHL
     AAFRARFYME PDTSDSGSMA SGAHTRGGGP LPGARSTKPA GNVAVRPLPD LKENVKRVMF
     YC