ID   EPFL3_ARATH             Reviewed;         107 AA.
AC   C4B8C4; A0A2H1ZEI3;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=EPIDERMAL PATTERNING FACTOR-like protein 3;
DE            Short=EPF-like protein 3;
DE   Contains:
DE     RecName: Full=MEPFL3 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=EPFL3 {ECO:0000303|PubMed:19435754};
GN   OrderedLocusNames=At3g13898 {ECO:0000312|Araport:AT3G13898};
GN   ORFNames=MDC16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19435754; DOI=10.1093/pcp/pcp068;
RA   Hara K., Yokoo T., Kajita R., Onishi T., Yahata S., Peterson K.M.,
RA   Torii K.U., Kakimoto T.;
RT   "Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL
RT   PATTERNING FACTOR 2 in Arabidopsis leaves.";
RL   Plant Cell Physiol. 50:1019-1031(2009).
RN   [4]
RP   3D-STRUCTURE MODELING, AND DISULFIDE BOND.
RX   PubMed=22027592; DOI=10.1038/ncomms1520;
RA   Ohki S., Takeuchi M., Mori M.;
RT   "The NMR structure of stomagen reveals the basis of stomatal density
RT   regulation by plant peptide hormones.";
RL   Nat. Commun. 2:512-512(2011).
CC   -!- FUNCTION: Controls stomatal patterning. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the plant cysteine rich small secretory peptide
CC       family. Epidermal patterning factor subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEE75435.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB019229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002686; AEE75435.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AB499312; BAH58782.1; -; mRNA.
DR   RefSeq; NP_001319546.1; NM_001338088.1.
DR   AlphaFoldDB; C4B8C4; -.
DR   SMR; C4B8C4; -.
DR   STRING; 3702.AT3G13898.1; -.
DR   PaxDb; C4B8C4; -.
DR   PRIDE; C4B8C4; -.
DR   EnsemblPlants; AT3G13898.1; AT3G13898.1; AT3G13898.
DR   GeneID; 10723043; -.
DR   Gramene; AT3G13898.1; AT3G13898.1; AT3G13898.
DR   KEGG; ath:AT3G13898; -.
DR   Araport; AT3G13898; -.
DR   TAIR; locus:6530298199; AT3G13898.
DR   eggNOG; ENOG502S87E; Eukaryota.
DR   HOGENOM; CLU_135272_0_0_1; -.
DR   InParanoid; C4B8C4; -.
DR   OrthoDB; 1540159at2759; -.
DR   PRO; PR:C4B8C4; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; C4B8C4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0010052; P:guard cell differentiation; ISS:UniProtKB.
DR   GO; GO:0010374; P:stomatal complex development; ISS:UniProtKB.
DR   InterPro; IPR039455; EPFL.
DR   PANTHER; PTHR33109; PTHR33109; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..107
FT                   /note="EPIDERMAL PATTERNING FACTOR-like protein 3"
FT                   /id="PRO_0000392501"
FT   CHAIN           57..107
FT                   /note="MEPFL3"
FT                   /evidence="ECO:0000303|PubMed:22027592"
FT                   /id="PRO_0000430509"
FT   DISULFID        64..102
FT                   /evidence="ECO:0000303|PubMed:22027592"
FT   DISULFID        68..74
FT                   /evidence="ECO:0000303|PubMed:22027592"
FT   DISULFID        71..104
FT                   /evidence="ECO:0000303|PubMed:22027592"
SQ   SEQUENCE   107 AA;  12512 MW;  F3BF0949CD3E0639 CRC64;
     MEYMFLLMSK FFFVFPIIIY IGPAEIIKPQ AAEENSRRRI LNPNENKEEI VKRRRRIGSK
     PPSCEKKCYG CEPCEAIQFP TISSIPHLSP HYANYQPEGW RCHCPPP