EPFL8_ARATH
ID EPFL8_ARATH Reviewed; 99 AA.
AC Q1G3V9; A0MDL4;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=EPIDERMAL PATTERNING FACTOR-like protein 8 {ECO:0000303|PubMed:19435754};
DE Short=EPF-like protein 8;
DE Contains:
DE RecName: Full=MEPFL8 {ECO:0000305};
DE Flags: Precursor;
GN Name=EPFL8 {ECO:0000303|PubMed:19435754};
GN OrderedLocusNames=At1g80133 {ECO:0000312|Araport:AT1G80133};
GN ORFNames=F18B13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19435754; DOI=10.1093/pcp/pcp068;
RA Hara K., Yokoo T., Kajita R., Onishi T., Yahata S., Peterson K.M.,
RA Torii K.U., Kakimoto T.;
RT "Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL
RT PATTERNING FACTOR 2 in Arabidopsis leaves.";
RL Plant Cell Physiol. 50:1019-1031(2009).
RN [5]
RP 3D-STRUCTURE MODELING, AND DISULFIDE BOND.
RX PubMed=22027592; DOI=10.1038/ncomms1520;
RA Ohki S., Takeuchi M., Mori M.;
RT "The NMR structure of stomagen reveals the basis of stomatal density
RT regulation by plant peptide hormones.";
RL Nat. Commun. 2:512-512(2011).
CC -!- FUNCTION: Controls stomatal patterning. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the plant cysteine rich small secretory peptide
CC family. Epidermal patterning factor subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28321.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC009322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE36361.1; -; Genomic_DNA.
DR EMBL; DQ487475; ABF59196.1; -; mRNA.
DR EMBL; DQ652630; ABK28321.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001077850.1; NM_001084381.3.
DR AlphaFoldDB; Q1G3V9; -.
DR SMR; Q1G3V9; -.
DR STRING; 3702.AT1G80133.1; -.
DR PaxDb; Q1G3V9; -.
DR PRIDE; Q1G3V9; -.
DR EnsemblPlants; AT1G80133.1; AT1G80133.1; AT1G80133.
DR GeneID; 5007859; -.
DR Gramene; AT1G80133.1; AT1G80133.1; AT1G80133.
DR KEGG; ath:AT1G80133; -.
DR Araport; AT1G80133; -.
DR TAIR; locus:4010713606; AT1G80133.
DR HOGENOM; CLU_135272_2_1_1; -.
DR InParanoid; Q1G3V9; -.
DR OMA; WICRCRD; -.
DR OrthoDB; 1565879at2759; -.
DR PhylomeDB; Q1G3V9; -.
DR PRO; PR:Q1G3V9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q1G3V9; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0010052; P:guard cell differentiation; ISS:UniProtKB.
DR GO; GO:0010374; P:stomatal complex development; ISS:UniProtKB.
DR InterPro; IPR039455; EPFL.
DR PANTHER; PTHR33109; PTHR33109; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..99
FT /note="EPIDERMAL PATTERNING FACTOR-like protein 8"
FT /id="PRO_0000392506"
FT CHAIN 46..99
FT /note="MEPFL8"
FT /evidence="ECO:0000303|PubMed:22027592"
FT /id="PRO_0000430514"
FT DISULFID 53..90
FT /evidence="ECO:0000303|PubMed:22027592"
FT DISULFID 57..63
FT /evidence="ECO:0000303|PubMed:22027592"
FT DISULFID 60..92
FT /evidence="ECO:0000303|PubMed:22027592"
SQ SEQUENCE 99 AA; 11321 MW; 4462513B5FF9EDFF CRC64;
MDSSRKYKRC GFGAALFVAN IFFSLLSLHC ISGAHGHQQR MKESVMGSEP PVCATKCRNC
KPCLPYLFDI RGAHDDDDDS EPYYPVKWIC RCRDRVFEP
