ID   EPG5_AEDAE              Reviewed;        2282 AA.
AC   Q0IEK6;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Ectopic P granules protein 5 homolog;
GN   ORFNames=AAEL009648;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Involved in autophagy. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EPG5 family. {ECO:0000305}.
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DR   EMBL; CH477600; EAT38457.1; -; Genomic_DNA.
DR   RefSeq; XP_001653908.1; XM_001653858.1.
DR   AlphaFoldDB; Q0IEK6; -.
DR   STRING; 7159.AAEL009648-PB; -.
DR   PRIDE; Q0IEK6; -.
DR   VEuPathDB; VectorBase:AAEL026253; -.
DR   eggNOG; KOG3622; Eukaryota.
DR   InParanoid; Q0IEK6; -.
DR   OMA; EHFLPMY; -.
DR   PhylomeDB; Q0IEK6; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   InterPro; IPR029651; EPG-5.
DR   PANTHER; PTHR31139:SF4; PTHR31139:SF4; 1.
PE   3: Inferred from homology;
KW   Autophagy; Reference proteome.
FT   CHAIN           1..2282
FT                   /note="Ectopic P granules protein 5 homolog"
FT                   /id="PRO_0000306258"
SQ   SEQUENCE   2282 AA;  260805 MW;  E5DF662523A9BD28 CRC64;
     MVPLSGEQLA QFYRVDGEMA LAEAFEKEFL TRELQENDQC MNHPLYQLLQ RYAKARAEFS
     LNVLEFEALR RKCKALANEL WTVREQTFAG TGTCGDGKVV HASHISSVAA LQESALADFS
     SNLQDLMKQS FFQCSQSTYE VDATRIKIEQ KIYETLNLHP VLSNLPADSP VVLNPPIDAM
     QLTAAIGELR LCISILFAFL RKGITDKRFL ADVRGWTVKL VATQLRIATV HDHLFVLFHV
     LRSPSGIANW ATSLVQLPTE QDLRWGSSEF QHILVVMACI LLPIKKRNEF LEKLKLDMNR
     SIDVVQEEMW AIVDSDGEDC SGSDSISELK EGDLVALIDQ IPFGMVFRAL TLVDRKLDGT
     WRLGEDQVRG THVMKAIAFG TIFVELLGNG LMTYNADRYR QFAKRVARLI KHTVYYVSDL
     YRILLERTRS VQVVLDDYET TRINLELDVF VVRAAQYIYR SRKIGTWQYL SGFPFDQLSV
     GALWKLYYFL HLDEFNEELI TAVGTDFRDL CIGPNQREKF RNGLVGMPSE DLYYLLQVFS
     NMALAREIDD FEFIETVALN LFDIGYLNEY TKDFCYKAVK DLLFNIVYKH PSLVSSLLQY
     MKQDVAQADH SALYVFKSLP LDRWRPQWDD FELLANWILN YGFDAVQSST ARVILIHLNY
     NFDSNNELFL PHDIHVRIAC LITEIYSKHV PELLGNPQGL VASVSSLVKN KTAQDQFLAW
     CWNMVSLLRL HCMDQSPTVI NGMMKNPALI LRYVLELERA QQIYQGVTEN RPLAIYLAIL
     ISTWGHSVPQ ICHQGFEQIR LLLNDHRYVV VVRCLQLITP LFLECPDSLS HCESFKSILI
     SLMAADKYYA RFTKDQFKPE SNSPCLTELP NWTKDPAIIG LLDAMAGVAY QFPDAWHSMK
     EFFRPYFSVS SIILHSPSSA TVFLSIFTLE LEYELTEIQS GIWHEVIRGI GLPSSPKLTI
     ETAIKKSTSI LGYPSFPPSS LAVFKLANLV ANCTIKNFMY PIVCQLFFTI YLSRLPLSTE
     EQRFANCFGV SDQIYECNVG LMKRIKKQLY DAECFYNSAS VSESDERQRS FYNHCTRLFK
     TFQLWLEDTQ LNKISTNAVN LPPQFDRYRL AAIFRGNRDH WTDFIDFRGI RSDHRDLADA
     WQKLCYRYKP EVSTVATNSP ARSLASSHSV TDLQDFKQSI FKRLETYDAP APAPLVFKPT
     PLIPPAKFTT QSSNSFLVMY NEHLLLDSFY LEQVPKLYIV EDKVLYKDAS CSNGCTESRK
     VLVRYKVSKL DKNLSAVLRE NRSAHEALLQ RESKLPDRIV MASVRIDAFL RQIVEAYREF
     KLSGETNVCA KLNKVGSTLF YEFVGKMNDY NQLCPLTKDV CSLGISQLGF FMRENQNDEG
     IKLLNITLGR PEMISLLSEL LVPASCPPQF FLRMYEFVID SHIKRHDTQV LFVMLSKFDI
     IAWMNRYRPK LVDVRRLVEL ILRGLEGWTQ KNAVLIQDLL QRHLMHLFEF DFPEYYGDIL
     QMVLAACSLK KIMAQVLLEL LNSMRRRVEC QPLTFGLGLV SIKEDFRSFA TKQKILSYKD
     LIDTTVLLTQ HFQQERLNHG LHGLYPVHSD YCEVLSLLLG SVGHATVVAA VHAYPGVLAD
     ELINWLWPPL CDMFSPWLTP YFPQNMKGQQ QVANWIQQVA SDSSILPPWS ELHSETAFRM
     VKVFEHCIQY LMDTFPSSSA LLGHLFSWYE LNFAHPALPR HVAVPIHTNL MNLAWDRFRP
     APVHITGFSR ILQQFIPEAH KFVGHIFIRI AWTPWLQQNI QSWDYQLRYQ MLSALLMIFI
     KISYEPNARE GLKIVTLLQE ACNYPWHMLE YQGVEAVLDW FVLSAEPSVV LKMPSESEVV
     DSAVLDLLQV ASSMKFNSGN PLESTALQSQ VQAKRILYVR TTVRLLNSCG AKYQKLLGTK
     QGVQAFHNAV LGLFNIVETV LLQIRSTKDR EFEARNLIGE VIVSLQSQGE YTSKLFTEAI
     VLWTENCRTS DSYIVPSVLD AVGMCKSFSL NLYLLLEEML FHYFGKSWHG QVNDGGDPVL
     DASWVKALHK VGLQTVKGFD EEMLVKHRCL LVLHLLTVQK LRTAGSSGER IVVLQKLFQL
     LENVKVSDQT ESKLILLWSL MAVVGVEIMK ASSNGQNHLL TLARYLQTCS KDAEGWGEGL
     LGAIGIRKDG ISIRRKVVAK CLSCIVFLLF GEDSGEALEA SESGPPSIDC ANRCKEYDQA
     MGDLKQTLTN KRYGDMHIKT RAAINLVENT AMIANIGENV CKIVRLFCDE HFFHSVEEVW
     RC