ID   EPG5_CAEBR              Reviewed;        1601 AA.
AC   Q61WP7; A8WX79;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Ectopic P granules protein 5;
GN   Name=epg-5; ORFNames=CBG04313;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Involved in autophagy. Has a role in the degradation of
CC       protein aggregates within autophagosomes. Essential for starvation-
CC       induced autotrophy and omegasome development (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EPG5 family. {ECO:0000305}.
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DR   EMBL; HE600920; CAP25045.3; -; Genomic_DNA.
DR   RefSeq; XP_002630374.1; XM_002630328.1.
DR   AlphaFoldDB; Q61WP7; -.
DR   STRING; 6238.CBG04313; -.
DR   PRIDE; Q61WP7; -.
DR   GeneID; 8571889; -.
DR   KEGG; cbr:CBG_04313; -.
DR   CTD; 8571889; -.
DR   WormBase; CBG04313; CBP42544; WBGene00027014; Cbr-epg-5.
DR   eggNOG; KOG3622; Eukaryota.
DR   HOGENOM; CLU_003383_0_0_1; -.
DR   InParanoid; Q61WP7; -.
DR   OMA; FECRLTE; -.
DR   OrthoDB; 42984at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR   InterPro; IPR029651; EPG-5.
DR   PANTHER; PTHR31139:SF4; PTHR31139:SF4; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Reference proteome.
FT   CHAIN           1..1601
FT                   /note="Ectopic P granules protein 5"
FT                   /id="PRO_0000306260"
FT   REGION          1..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..98
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1601 AA;  179970 MW;  81D80A43A29EAA5F CRC64;
     MAELVRPKKP KHRERPQSDD APRIPDRPVM VNGMRLPVAP SHSIQHQRDR SASPEPEEQV
     LSDTGESINP EKENGSIQDV RSSPVRPAPP PPRAISQERE APPIPARNLV FPRSTSMVAE
     STREPTPVVL PKRSVAVAPY PTVPELAELP SYTAALKHPQ VYPAVDGGQL HHSRSAAAIP
     EKTRFSAPVA QERVREGEAP PMYPSINTYE RNEHGLMTEE NLVTFYHNPL YEHAEIFVDQ
     FIKAEVVPNQ SGSLFPLLAR LKSVCDLMTV SEVKGKENTE ELQKCLRECW VQQTMSVEAK
     GKCGDNNDGT GRASYFSYEL QQSVLDQMKR LLSTNRTNLL DHTLCEETSF RSLALQIQWQ
     IIIINNNFMA ENGLTTNCPP SLVATGPMTP GRTAIRTALS DIFYHLRYPR LSKRFIDTLF
     GWIKELTCIL NMRQSCDDGI FLLCHLLRLP SPIDHWAPPF VQTFIQSQSP PRLKLDYCVA
     LLTHLLNPIK ARESFLRHVA QSEKEESTWE ILADDDDGEA NEFSFVTINE SDLTAFLDQI
     PISELYSIAY LAFTSYSDKG SQFTAMIAFQ LLLMKILDNG LTSYSQPGYK MFCKQIGISL
     KHSVRELCSN WRLIRDQIRP GEEQNLQKEV DRIVLLALNY LIHRDSVGLF QFVVALPYGV
     VSEECRSRCE YALRSNKKMS IHEIYETPIC EVRARISSQS IAKRVSSLGA QDSEFLINSL
     ASIGSYSNGD VGQLLKELID VCFCEPATRD DFYKCGGEAI GQILTKRPET LHQLLAIVDR
     NLQHMDSYAI NVLSSSRLFE CRLTEPMISI IGKWLINNPP EHGANRLARR VLSGLHWGLG
     PDGQNLWIDV DVHAIAADTV VKAHSVHCSR SNSMISKSIS KISKLASKVG DAESLFQQFC
     WDLLVKLKLP TIPVDLVQND LTAHYVRIVQ NYEDDVVVYL EKAVPLLSDL VSSGSSVASV
     VLLSRLIAQH YQKVNLMAAD KNFMATFERL LHIDQLPYAV QWLSGPSSTP TPIVRLICSA
     ISYYSAKLPP RDYLRAWITL LCQARTGWNE DAVTYQIVGT IARIAFINDT QKLYEITSIV
     FQAYQQQMAA EKNQSKGILA LFSSDSSASP LIPDSMLAVS PFASYIMLRV EQKSFNPFYG
     HFYETLGKKD KYNLDHAAKK AASKCSMALP VERLAVFRWA KLVIVCKDSA LLPIILQQLA
     GQAYRLRKAN NLNLCYARRL IDEPQMQGVM AECRKAIEET TVATKGLSKA VVGWLFTKHE
     VTRTGFDFSV FDLDYLLQLI LAGDKNMWMD FVNMPHFTSE EFAERKLYSV TCQLSPKNRE
     SPSPPELGSP RARGTAKPFP VLPVHSGLPK APCLDPSTIF QQHVVLQMAA PFMSTVKNLA
     KQYTECGDRM DIYDDAYCKL IRILYQSTQQ TVPVEIRCSY CSKPKPCTMT VKPNVLSPEI
     DVKMSQNRQK RIEFWNELNA SMIDQAAVAT ASMEHLSRLV SMMAAALDPR NRNSVQPTGH
     SLFYLITSSV GENELLFSVA SESYSHSLRA LGEEFVKFRP EEQMDVMQLA LNGFVLSEPL
     VEVFTAEVLN SDDLCTAYRK LSDAVRMPER SKMALQLLGE Q