ID   EPG5_DANRE              Reviewed;        2532 AA.
AC   A5WUT8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Ectopic P granules protein 5 homolog;
GN   Name=epg5; ORFNames=si:dkey-165i4.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Involved in autophagy. May play a role in a late step of
CC       autophagy, such as clearance of autophagosomal cargo (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EPG5 family. {ECO:0000305}.
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DR   EMBL; CR753867; CAN88788.1; -; Genomic_DNA.
DR   RefSeq; NP_001103995.1; NM_001110525.1.
DR   AlphaFoldDB; A5WUT8; -.
DR   SMR; A5WUT8; -.
DR   STRING; 7955.ENSDARP00000121482; -.
DR   PaxDb; A5WUT8; -.
DR   PeptideAtlas; A5WUT8; -.
DR   Ensembl; ENSDART00000144525; ENSDARP00000121482; ENSDARG00000059846.
DR   GeneID; 569543; -.
DR   KEGG; dre:569543; -.
DR   CTD; 57724; -.
DR   ZFIN; ZDB-GENE-070705-307; epg5.
DR   eggNOG; KOG3622; Eukaryota.
DR   GeneTree; ENSGT00390000007354; -.
DR   InParanoid; A5WUT8; -.
DR   OrthoDB; 42984at2759; -.
DR   PhylomeDB; A5WUT8; -.
DR   TreeFam; TF313847; -.
DR   PRO; PR:A5WUT8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000059846; Expressed in retina and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR   GO; GO:0061909; P:autophagosome-lysosome fusion; IMP:ZFIN.
DR   GO; GO:0060576; P:intestinal epithelial cell development; IMP:ZFIN.
DR   GO; GO:0036335; P:intestinal stem cell homeostasis; IMP:ZFIN.
DR   InterPro; IPR029651; EPG-5.
DR   PANTHER; PTHR31139:SF4; PTHR31139:SF4; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Reference proteome.
FT   CHAIN           1..2532
FT                   /note="Ectopic P granules protein 5 homolog"
FT                   /id="PRO_0000306257"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          78..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          254..282
FT                   /evidence="ECO:0000255"
FT   COILED          1569..1596
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        53..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2532 AA;  286825 MW;  B24637F2388AB52E CRC64;
     MLHLQVKKER QSESVRQPSG SSKAVNEPEF TDVPLSLPHV PPDLNTAASQ TSLDHHDKAE
     NEQQHVLLCE KPEVVQKSTC HEDKEHELPS QDAAPRLDQT SVLAPSSQSD PKPLSAKLEP
     FSVPSIYPSI PASLSQPQLS EDSYSISYEL LDGSLMPAAS ERLVAPAVLT LANQESSPPS
     LVPVEVVDVE RSRERLYPEL PKTCQSVKPF TSEQLRMWEP GSWLENVELH EAEFQNLAHQ
     EGHELYELLL SYWRCRKQLT QAQTELQAAN SDCKNVQNRL WSFKDERLSL QGICADQNKV
     YGYHCYQQVT LNEAALAELK HLFSAKAEIL HQTVALHSYT SILSRLQVES YLYRLLSSNP
     TTKSVAVQDT SAGNPKSQPS SLQPLKESIS VLFIFTRRVL DDSQFQADIH LWLQRLVSVL
     HQVGSTGDHL FILNHLLCCP AGVGKWAVPF LQIKVLDNPS GVYHFMQALA ILMSPARHRP
     DFLGHMKPSD ARGNNSLTEP ASGNWTLVDE GGEEDEDPET SWMLLSEDDL VSLFSQFPFD
     ELFKHLLGIC SKGDYQPLAT TSQKMMKIFA FASSLVELLA VGLQTYNRAR YRQFVKRIGH
     MIRMTLCYVS DHWAQYISLT GVSRTTVQEQ SFSMEKLQVE FDHLFLRAVL HVLKAKRLGI
     WLFMSEMPYG TLSSSMLWKI FYIMQCAETD GLEKLSCSLS AEDCIQRLRE SSHQERFQLW
     LSEINSSDGI CLLTTFAHMA QPRRTDVDPE FVRNIVLEIY EVSYVSVTTR EIFSKVGREL
     LAAIAAAHPH IISVLLERLR ETIERVGMVS LYLFKELPLH LWMPAQEEVG LIRDWLMNFS
     LTAVENRLAC IILEGLNWGF QPNGCLILPA PLHSDVALLV IEAYQKYLTD KPYGGILSEG
     IKQVSYLANV VRLGQTPESS FNQWAWDIVL RLKLHANERS PQDAWCPLPS SSAPSVPEIT
     DSPIMHPVFK AVKAGIPIGC FLAIEMTTIG HSLEKFCSEG ISLLKTLIQS RHLRAAVHIL
     ENILPLVYNC QFYLLKNEQF LSCVQLFLQL DSGTQGVTQQ VTQKVAQHLI GPATCENIKL
     LNSVIQAHVL ESSRNGRVGA VAVLEFWLQV LTEQSLWYRD RAVLFLLDHM CRSAFLHQQE
     ECLQKILYQQ HKSALGYHGD KGLLSSIMGW IVAGNVTPSF IEGSSLTGEV WFAWMILNME
     TMFEEDSQLR RCVEHELLSN PACTPDQALK KAQVRLKLQV VPSLQRLMIY RWAQQALATP
     ADHPILPLVW QKFFQLYLRQ PGPEFGLEVK GCIGRRYFHS AAHLSLLKSL RQRLVEVSDF
     HHAASKALKV PCASGDSGDG LLTPGTPITQ YMTSPDLHTE IVRLFTVFAL WLDDENLQKQ
     EIYLPSLPKQ YDTHRLAKIM QRQQEVWMEH VDIERVQHEL QEVLDLWSKV KSEPAVSQNS
     SSSIFTDFIN PLAARERILT HLRKHDAPQG SLLPVPMKAP VPDIPTASLT DEKISTTLIQ
     EDLTKLQHQA KLATVRETQQ VALDNELLEV LPQLYINRED QLSMQLECRG KSGQPCQGPA
     NITVKYSSMH KLEPVQNQIQ SLKSDIKQLQ ADGIKAPPQS LAEAAVHTEN FITALVNVFK
     QNPSPGVLKV GITAFYQIVS FVCEDTQRHP PTRQFFTSCI EILGQVFIRD VQSECKHMLK
     TILLNRRLCN LLSPYFTPNA SPSELVSLYE EVVNTLHIDS GDVIFMLLTK FDLFQWLSTT
     QPPFSERSRL MTVIHQALCT CGLEPEPEVL MPFNIFCKHW TELLLYQFPD HYSDFLRLLM
     QSSSDQLLSP DCWRTSLKAL GCSPQTKNKT NKSRSMLLSP QQVDETIEWL SKYFLKLRLS
     NGDFRSFGLL SKWGPYIEEV KVFWEDLITY VIDLELNHCG KEPVGSPRLL KALENLHRKM
     AKLFEPWILV LDTDNTSHPR CSPWLESDAA VAASLVGLYT RLTETLHEKF KDRLLPGQRG
     ALWLHLMFYC ETCTSPKMPE YLLYTYHTEY SRLPWKDLHP DQTLMNQFFN VERGSPKSCF
     VFMGELLCEV NWVSVLSDSL SPQLNPSTHT MVVSVLHLMV FLAKEDLSKP ESSVLSLLDQ
     SASLPWNLVD FSSYQNVTRY VSTHYPASLV LSHDTSSQQV VRLLRMAAGF EPTTQVLHHK
     DMTLKCQAFL HLMVQFLTSL DQNGNISLAS LETEMEKLLE NIVIFNPPET DLQQRHMATC
     SLFAEMLTLL NEAGISTAEG LGTKLHCWVE KRARGPLLLP LLTAACRCLA SVRHMTRTTE
     ACILSYFTDG CVDQYSGWGP ILVSLQVPEL TVEDFIQESL SLGSFLTLYV YILQRLNLEQ
     TLLNEKKTLM LLNTWISQVF PSGPADEAKL FLWWHKFLEL LQIQVDQEDA CSLDTLILTL
     MAFQNRLVQL GEERLNSGIL GAIGLGRKSP LSNRFRVVAR SMSAFLLVQV PSENQLRLHP
     GTELQLSAKA QQALSALEAM ASNKQYSELH VSVNQACQFI KYPNHCLRDA NTLLTLLVNA
     LYTDLHYLDI IR