EPGN_CHICK
ID EPGN_CHICK Reviewed; 151 AA.
AC Q5EG71;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Epigen;
DE AltName: Full=Epithelial mitogen;
DE Short=EPG;
DE Flags: Precursor;
GN Name=EPGN;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RA Wang Y., Li J., Leung F.C.;
RT "Cloning of chicken ovarian epigen and regulation of its mRNA expression in
RT the cultured ovarian granulosa cells.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes the growth of epithelial cells. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AY885230; AAW79578.1; -; mRNA.
DR RefSeq; NP_001012404.1; NM_001012404.1.
DR AlphaFoldDB; Q5EG71; -.
DR SMR; Q5EG71; -.
DR STRING; 9031.ENSGALP00000017636; -.
DR PaxDb; Q5EG71; -.
DR Ensembl; ENSGALT00000017657; ENSGALP00000017636; ENSGALG00000010859.
DR GeneID; 497270; -.
DR KEGG; gga:497270; -.
DR CTD; 255324; -.
DR VEuPathDB; HostDB:geneid_497270; -.
DR eggNOG; ENOG502S4QW; Eukaryota.
DR GeneTree; ENSGT00510000048556; -.
DR HOGENOM; CLU_144237_0_0_1; -.
DR InParanoid; Q5EG71; -.
DR OMA; DKPSCIC; -.
DR OrthoDB; 1425022at2759; -.
DR PhylomeDB; Q5EG71; -.
DR TreeFam; TF335931; -.
DR Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-GGA-179812; GRB2 events in EGFR signaling.
DR Reactome; R-GGA-180292; GAB1 signalosome.
DR Reactome; R-GGA-180336; SHC1 events in EGFR signaling.
DR Reactome; R-GGA-182971; EGFR downregulation.
DR Reactome; R-GGA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-GGA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Reactome; R-GGA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-GGA-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q5EG71; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000010859; Expressed in granulocyte and 5 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:HGNC-UCL.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; ISS:HGNC-UCL.
DR GO; GO:0008083; F:growth factor activity; ISS:HGNC-UCL.
DR GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; ISS:HGNC-UCL.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:HGNC-UCL.
DR GO; GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; ISS:HGNC-UCL.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:HGNC-UCL.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:HGNC-UCL.
DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISS:HGNC-UCL.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR015497; EGF_rcpt_ligand.
DR PANTHER; PTHR10740; PTHR10740; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; EGF-like domain; Glycoprotein; Growth factor; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..151
FT /note="Epigen"
FT /id="PRO_0000045464"
FT TOPO_DOM 19..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 54..94
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 58..71
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 66..82
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 84..93
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 151 AA; 17030 MW; FD84D255218CA85A CRC64;
MAFGMLIYIL LKAMGALSEE AALTASSLST ELWNSWTKNN TEAYYAEQPR LLKLMQTCLE
EHHSYCINGL CAFHSELRKP ICKCLAGYNG ERCEHLTLNS YAHNSYERYI AVGIGIGILT
SGILAIIYCY VRKRCRKLKS PYKVCMGETA L
