EPHD_MYCTO
ID EPHD_MYCTO Reviewed; 592 AA.
AC P9WGS2; L0TBU4; P66777; Q10402;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 38.
DE RecName: Full=Probable oxidoreductase EphD;
DE EC=1.-.-.-;
GN Name=ephD; OrderedLocusNames=MT2270;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000516; AAK46556.1; -; Genomic_DNA.
DR PIR; G70786; G70786.
DR RefSeq; WP_003411445.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WGS2; -.
DR SMR; P9WGS2; -.
DR EnsemblBacteria; AAK46556; AAK46556; MT2270.
DR GeneID; 45426190; -.
DR KEGG; mtc:MT2270; -.
DR PATRIC; fig|83331.31.peg.2445; -.
DR HOGENOM; CLU_511581_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProt.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase.
FT CHAIN 1..592
FT /note="Probable oxidoreductase EphD"
FT /id="PRO_0000428312"
FT DOMAIN 30..286
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000255"
FT ACT_SITE 474
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 461
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 592 AA; 64030 MW; FF8434097B28D093 CRC64;
MPATQQMSRL VDSPDGVRIA VYHEGNPDGP TVVLVHGFPD SHVLWDGVVP LLAERFRIVR
YDNRGVGRSS VPKPISAYTM AHFADDFDAV IGELSPGEPV HVLAHDWGSV GVWEYLRRPG
ASDRVASFTS VSGPSQDHLV NYVYGGLRRP WRPRTFLRAI SQTLRLSYMA LFSVPVVAPL
LLRVALSSAA VRRNMVGDIP VDQIHHSETL ARDAAHSVKT YPANYFRSFS SSRRGRAIPI
VDVPVQLIVN SQDPYVRPYG YDQTARWVPR LWRRDIKAGH FSPMSHPQVM AAAVHDFADL
ADGKQPSRAL LRAQVGRPRG YFGDTLVSVT GAGSGIGRET ALAFAREGAE IVISDIDEAT
VKDTAAEIAA RGGIAYPYVL DVSDAEAVEA FAERVSAEHG VPDIVVNNAG IGQAGRFLDT
PAEQFDRVLA VNLGGVVNGC RAFGQRLVER GTGGHIVNVS SMAAYAPLQS LSAYCTSKAA
TYMFSDCLRA ELDAAGVGLT TICPGVIDTN IVATTGFHAP GTDEEKIDGR RGQIDKMFAL
RSYGPDKVAD AIVSAVKKKK PIRPVAPEAY ALYGISRVLP QALRSTARLR VI