EPHX4_MOUSE
ID EPHX4_MOUSE Reviewed; 359 AA.
AC Q6IE26; F8VQ47;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Epoxide hydrolase 4;
DE EC=3.3.-.-;
DE AltName: Full=Abhydrolase domain-containing protein 7;
DE AltName: Full=Epoxide hydrolase-related protein;
GN Name=Ephx4; Synonyms=Abhd7, Ephxrp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP IDENTIFICATION.
RC STRAIN=C57BL/6J;
RX PubMed=15060002; DOI=10.1101/gr.1946304;
RA Puente X.S., Lopez-Otin C.;
RT "A genomic analysis of rat proteases and protease inhibitors.";
RL Genome Res. 14:609-622(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Epoxide hydrolase
CC family. {ECO:0000305}.
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DR EMBL; AC126598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BN000367; CAE51855.1; -; mRNA.
DR CCDS; CCDS19501.1; -.
DR RefSeq; NP_001001804.2; NM_001001804.2.
DR AlphaFoldDB; Q6IE26; -.
DR SMR; Q6IE26; -.
DR STRING; 10090.ENSMUSP00000043764; -.
DR ChEMBL; CHEMBL4295863; -.
DR ESTHER; mouse-ephx4; Epoxide_hydrolase.
DR PhosphoSitePlus; Q6IE26; -.
DR PaxDb; Q6IE26; -.
DR PRIDE; Q6IE26; -.
DR ProteomicsDB; 275762; -.
DR Antibodypedia; 33635; 92 antibodies from 17 providers.
DR DNASU; 384214; -.
DR Ensembl; ENSMUST00000049146; ENSMUSP00000043764; ENSMUSG00000033805.
DR GeneID; 384214; -.
DR KEGG; mmu:384214; -.
DR UCSC; uc008yme.1; mouse.
DR CTD; 253152; -.
DR MGI; MGI:2686228; Ephx4.
DR VEuPathDB; HostDB:ENSMUSG00000033805; -.
DR eggNOG; KOG4178; Eukaryota.
DR GeneTree; ENSGT00940000156233; -.
DR HOGENOM; CLU_020336_7_3_1; -.
DR InParanoid; Q6IE26; -.
DR OMA; YRWMVRS; -.
DR OrthoDB; 616687at2759; -.
DR PhylomeDB; Q6IE26; -.
DR TreeFam; TF314403; -.
DR BioGRID-ORCS; 384214; 0 hits in 74 CRISPR screens.
DR PRO; PR:Q6IE26; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6IE26; protein.
DR Bgee; ENSMUSG00000033805; Expressed in olfactory epithelium and 132 other tissues.
DR ExpressionAtlas; Q6IE26; baseline and differential.
DR Genevisible; Q6IE26; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..359
FT /note="Epoxide hydrolase 4"
FT /id="PRO_0000281379"
FT TRANSMEM 15..35
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT DOMAIN 92..337
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000255"
FT ACT_SITE 167
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 279
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 334
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 359 AA; 41477 MW; 27871F1D051BAA5C CRC64;
MAPPRPPRLL PALRALLYWS LVYGYCGLCA SVHLLKLLWS IGRAPAQTFR RAARANPPAC
LNDPSLGTHC YVRIKDSGLR FHYVAAGERG KPLMLLLHGF PEFWYSWRHQ LREFKSEYRV
VALDLRGYGE SDAPAHQESY KLDCLIADIK DILDSLGYSK CVLIGHDWGG MIAWLIAVCY
PEMIMKLIVI NFPHPSVFTE YILRHPAQLF RSSFYYFFQI PRFPEFMFSI NDFKALKHLF
TSQSTGIGRK GRQLTTEDLE AYVYVFSQPG ALSGPINHYR NIFSCLPLKH HMVTTPTLLL
WGEEDAFMEV EMAEVTKIYV KNYFRLTILS EGSHWLQQDQ PDIVNGLIWA FLKEETRRD
