ID   EPIB_STAEP              Reviewed;         986 AA.
AC   P30195;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Epidermin biosynthesis protein EpiB;
GN   Name=epiB;
OS   Staphylococcus epidermidis.
OG   Plasmid pTu 32.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TU 3298 / DSM 3095;
RX   PubMed=1740156; DOI=10.1111/j.1432-1033.1992.tb16605.x;
RA   Schnell N., Engelke G., Augustin J., Rosenstein R., Ungermann V., Goetz F.,
RA   Entian K.-D.;
RT   "Analysis of genes involved in the biosynthesis of lantibiotic epidermin.";
RL   Eur. J. Biochem. 204:57-68(1992).
CC   -!- FUNCTION: Involved in the post-translational modification of the
CC       lantibiotic epidermin.
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Note=Possibly associated with, and
CC       anchored to, the cytoplasmic side of the membrane.
CC   -!- SIMILARITY: To B.subtilis SpaB and L.lactis NisB. {ECO:0000305}.
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DR   EMBL; X62386; CAA44253.1; -; Genomic_DNA.
DR   AlphaFoldDB; P30195; -.
DR   SMR; P30195; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006827; Lant_deHydtase_N.
DR   InterPro; IPR023809; Thiopep_bacteriocin_synth_dom.
DR   Pfam; PF14028; Lant_dehydr_C; 1.
DR   Pfam; PF04738; Lant_dehydr_N; 1.
DR   TIGRFAMs; TIGR03891; thiopep_ocin; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Plasmid.
FT   CHAIN           1..986
FT                   /note="Epidermin biosynthesis protein EpiB"
FT                   /id="PRO_0000086986"
SQ   SEQUENCE   986 AA;  116708 MW;  343CE98526847850 CRC64;
     MDNIFVPSNI YMVRTPIFSI ELYNQFLKSD NIDYDLILQN DIFKESIMTT TYNLYQSIGK
     IDWEKDNKKT RNVKESLLKY LIRMSTRSTP YGMLSGVALG EFSENNNIKI KDSSFHKKDV
     KIDGQWLYKL VHYLESDYTY YKDSFVIWNQ QNYIYNNRLY LDNNSSITEN KRNDVLSVKY
     NSILVFIHEN SKKNITYEEL VQLISSKYSI ENKEEVKVFV QELINKEIIF SDLRPTLENK
     NPLDYIINSL NPKNSLVGTL INISNEITKY SKMPLGKGEY KYLDIVNLMS QLFVSKNYLQ
     IDTYIDYSRN ELKQSLADNI SEAAYILWLL SPNHFGTKTI RNYHEFFMDK YGFEQLVNLK
     QLLSDINGFG YPKKDSYSFS NNIAFLKEKY LLAIQNNSHI EITENDVKNL EKNNTVSKIN
     APVSTEIYSE IYFGNSIKGY EDFAVISPIL GSFNAGATFG RFTGNFNIKK KNQLQKEIVH
     HYNNYMNENG LEISQLNEGP LNSRNVNILN NNRIYNTCLN LNLPKSDIDI NDIFIGATFN
     KLYLYSEKHD SRIVFVSNSM FNYEFGSELY KFLREISFEK TKFIQPITEE GIDSLPFCPR
     IIYKNIILKP ATWKINSEMF SETENWLNRF ATIREKWHIP KDVIIAFGDN RLLLNLLNDK
     HLIILKKELK KHGRIRILES FINESNNERM LEIVTPLYKK TSLKEQSFII PKNRNKHFNN
     LKDWFSIHLS IPKTYQDNFI QDYLLPFITE LKVNNFINKF FYIKFKEDED FIKLRLLRED
     EDYSQIYSFI KNWKDYCLLN SELYDYSIVD YVPEVYRYGG PHVIEDIENF FMYDSLLSIN
     IIQSEFKIPK EFIVAISIDF LLDYLEINKS EKEEILINNA EDLYRSNDIR EYKNLLAKLT
     NPKNDYEILK KEFPNLHEFL FNKISILENL KKTLQKSLYT SRSRIIGSFI HMRCNRIFGI
     NPEKEKFVLS IFNEITKTKK YWDGCD