ID   EPL1_ASHGO              Reviewed;         742 AA.
AC   Q752Q3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Enhancer of polycomb-like protein 1;
GN   Name=EPL1; OrderedLocusNames=AFR520W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 353.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair. Involved in gene silencing by neighboring
CC       heterochromatin, blockage of the silencing spreading along the
CC       chromosome, and required for cell cycle progression through G2/M (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the enhancer of polycomb family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53891.2; -; Genomic_DNA.
DR   RefSeq; NP_986067.2; NM_212203.2.
DR   AlphaFoldDB; Q752Q3; -.
DR   SMR; Q752Q3; -.
DR   STRING; 33169.AAS53891; -.
DR   EnsemblFungi; AAS53891; AAS53891; AGOS_AFR520W.
DR   GeneID; 4622346; -.
DR   KEGG; ago:AGOS_AFR520W; -.
DR   eggNOG; KOG2261; Eukaryota.
DR   HOGENOM; CLU_010580_0_0_1; -.
DR   InParanoid; Q752Q3; -.
DR   OMA; TYIKFSA; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0000786; C:nucleosome; IEA:EnsemblFungi.
DR   GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; IEA:EnsemblFungi.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR024943; Enhancer_polycomb.
DR   InterPro; IPR019542; Enhancer_polycomb-like_N.
DR   PANTHER; PTHR14898; PTHR14898; 1.
DR   Pfam; PF10513; EPL1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..742
FT                   /note="Enhancer of polycomb-like protein 1"
FT                   /id="PRO_0000214155"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  86365 MW;  8B8F248919375E70 CRC64;
     MPTPSAQLDQ GIISSNGGTS GVSASSTRFR HRKISVKQKL RVYKASDLKD LDQDELQQRE
     LQEIETGVEK NEEREVHLHK ILQKNQLQLQ DLYIPTPDAS RVWKEFDEMY QGRFTTPASY
     IQFSVQLEDC CGPAYNMDER DEAYLAELNG GESEALTEDE FELLMTNFES AIRERQPFLA
     MDPESLLMYE DLKPTMLKND IGDAGLKTEL AAELQLGDQP FVTKFDSPAT LRTRNMVELI
     EKYGAEVYEY WKKRKVEVAG GSIIPSLKAE RSTDKDDNDP YFCFRRREVR QTRKTRRVDT
     QNSQKLRLLY QQLQYTKELA LLVAKREKMS MDMLLRDREI FQLRCDIKTV KRGLGIKGED
     ELLISQKRRK LVSNVITNKK YVSTQADAAA LRRLRVAKVK DKKLLSKQLS STDLKRQQSQ
     LQKLDQQQRQ QQQQQQPQIN GAQCQQDGSG VSHVYVKLPT SKIPDIVLED VDKVLSMKER
     NTKRFVEEKM KKRREEDGDI FFNLTDDPYN PVFEITIPQN ISPTNAPFSS IVSSNFEISR
     SYYTPNLQNC ITGNTNSVLA YNKEGEIVES QKYKKIEFYS PFEEKNDSHT REIPVRFRRR
     LGRYGVEYID RKDVSRNPSD LLGEFMDFSL IAEQEQSSDA VNVYDSQLDE LFRLHDKWKY
     DSDHNAYGIK FSDEPSRLNQ ISNETQVIRF GTMLGTKSYE QLREATLKYR QNVMAQRKKL
     VNAQRQQQQQ QQEQQEQEHQ QA