EPL1_GIBZE
ID EPL1_GIBZE Reviewed; 590 AA.
AC Q4I5V3; A0A098DNR4; A0A0E0S989; I1RTA4; V6RI92;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Enhancer of polycomb-like protein 1;
GN Name=EPL1; ORFNames=FGRRES_07405, FGSG_07405;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family. {ECO:0000305}.
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DR EMBL; DS231666; ESU13667.1; -; Genomic_DNA.
DR EMBL; HG970335; CEF83002.1; -; Genomic_DNA.
DR RefSeq; XP_011327174.1; XM_011328872.1.
DR AlphaFoldDB; Q4I5V3; -.
DR SMR; Q4I5V3; -.
DR STRING; 5518.FGSG_07405P0; -.
DR PRIDE; Q4I5V3; -.
DR EnsemblFungi; ESU13667; ESU13667; FGSG_07405.
DR GeneID; 23554483; -.
DR KEGG; fgr:FGSG_07405; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G24745; -.
DR eggNOG; KOG2261; Eukaryota.
DR HOGENOM; CLU_010580_1_0_1; -.
DR InParanoid; Q4I5V3; -.
DR Proteomes; UP000070720; Chromosome 4.
DR GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; PTHR14898; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..590
FT /note="Enhancer of polycomb-like protein 1"
FT /id="PRO_0000214162"
FT REGION 302..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 67013 MW; 8513E9432445A80C CRC64;
MSSRKVRVKK LNVKTTLPVL REDQIDPNEY EALTTDNQIA TGVEQAEENE YHLQTILKEA
GTSNDQEIPV PPPQESDINY DDLYPVPFHK PSSYIRFSQT VEECITCLYD MTTEDDEFLK
QYNSKPPATG VLSEDDFEHI MEVFEDTAAE QTPFAAVDNT VAAYDMMLPG LTHLNQSVST
DVLQHAKPVY EYWKSRRQEA GNKPLHPSLK FETHQETDDT DPFVCFRRRE ARQTRKTRAR
DNKIAETLKK LRRELEDGRQ LVLLAYEREM VKREVMSMDR AIFEERARLK DMKLRLGIKG
EDEDLVNQKP QKRKPVEPPV VRQPTGAHLR QPVRSDGRTL DADLVLLSDK LAEKETELRL
DIEMKVQNHR KWNQNHIDLT REPLSPVKEQ GTEVKFRQAK TQYLMTPPAS TSSEMEVDEI
APDAMQLDKR ESSVFQFTAG SGEQSKGSQP AFRRRIGRLN RLWIDRRGMV TPPRELGEDR
SDRWKYDSDS DDEEPPVYEV DPFDTRALKF RATIPLNPYM FRGRPAVPPE AVAAAQAQAG
NRVLPSPAAA AAHAHAQAHA QAAAAAHLAA QAQAKAQAVA QQQAQAAQGV
