EPL1_SCHPO
ID EPL1_SCHPO Reviewed; 557 AA.
AC Q9UU94;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Enhancer of polycomb-like protein 1;
GN Name=epl1; ORFNames=SPCC830.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family. {ECO:0000305}.
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DR EMBL; CU329672; CAB52878.1; -; Genomic_DNA.
DR PIR; T41631; T41631.
DR RefSeq; NP_588475.1; NM_001023466.2.
DR AlphaFoldDB; Q9UU94; -.
DR SMR; Q9UU94; -.
DR BioGRID; 275993; 2.
DR IntAct; Q9UU94; 2.
DR MINT; Q9UU94; -.
DR STRING; 4896.SPCC830.05c.1; -.
DR iPTMnet; Q9UU94; -.
DR MaxQB; Q9UU94; -.
DR PaxDb; Q9UU94; -.
DR EnsemblFungi; SPCC830.05c.1; SPCC830.05c.1:pep; SPCC830.05c.
DR GeneID; 2539428; -.
DR KEGG; spo:SPCC830.05c; -.
DR PomBase; SPCC830.05c; epl1.
DR VEuPathDB; FungiDB:SPCC830.05c; -.
DR eggNOG; KOG2261; Eukaryota.
DR HOGENOM; CLU_010580_1_0_1; -.
DR InParanoid; Q9UU94; -.
DR OMA; HIKWNEG; -.
DR PhylomeDB; Q9UU94; -.
DR PRO; PR:Q9UU94; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000785; C:chromatin; NAS:PomBase.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; ISO:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; ISO:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:PomBase.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; PTHR14898; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..557
FT /note="Enhancer of polycomb-like protein 1"
FT /id="PRO_0000214165"
FT REGION 323..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..342
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 557 AA; 64628 MW; 884CE3D8559EA724 CRC64;
MSSVSKNARA YRQRKVGIKT VMPIYFERDI PDFDEEASLQ RTVPLVESGV EKEEEEEKHL
QQVINEAHEA IVRGSEKKLI IPTREAKNIG IIDKYYKKNF ILPKTLIRFS LTVEECTNPE
YCMDEHDTEY FLKLKQAQPS LSKFSELDFE IVMQTFEEEI NQNQPFLSMD TSQILPLSEL
ITSFELKDVL YLKPLASQVY PYWRERRISK GGLPIMAKAQ VGDDKDDDDP YVCFRRREIR
QARKTRRSDA QSYDRLRRLR QSMETSLQLL EQVYKREQKK LQALEDDYAI FQKRCLVKKL
KRTLNIKDSD ELLINPKRRP IEVKPAAPVP TPAPPVKTSP HPASYRPQPT RNVEVRPLLM
LDDVQSAQIT QFQIRLQQRL TKKEQLDRNW VDLLETPSTV IHTNYPDSFY RNIIPYYSGK
ETKQSHNQLS IPSSTPSTPL SDNGPTYSTP HSSLSNFNTC DSLSFSSNNS LYGYSTLLHP
RNPICVRQRI GRGGRLMLDR TRALPVHRLS KPKSRVEDRW LFDIPFDADD TIILDDESDA
SIMFRASLLN DDMGTQS
