EPMIP_MOUSE
ID EPMIP_MOUSE Reviewed; 606 AA.
AC Q8VEH5; Q80TS4;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=EPM2A-interacting protein 1;
DE AltName: Full=Laforin-interacting protein;
GN Name=Epm2aip1; Synonyms=Kiaa0766;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-606.
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Liver, Lung, Pancreas, and
RC Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with EPM2A. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
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DR EMBL; AK030084; BAC26774.1; -; mRNA.
DR EMBL; AK032284; BAC27793.1; -; mRNA.
DR EMBL; BC018474; AAH18474.1; -; mRNA.
DR EMBL; AK122366; BAC65648.1; -; mRNA.
DR CCDS; CCDS40785.1; -.
DR RefSeq; NP_780475.1; NM_175266.4.
DR AlphaFoldDB; Q8VEH5; -.
DR BioGRID; 218916; 9.
DR IntAct; Q8VEH5; 2.
DR STRING; 10090.ENSMUSP00000052904; -.
DR iPTMnet; Q8VEH5; -.
DR PhosphoSitePlus; Q8VEH5; -.
DR EPD; Q8VEH5; -.
DR jPOST; Q8VEH5; -.
DR MaxQB; Q8VEH5; -.
DR PaxDb; Q8VEH5; -.
DR PeptideAtlas; Q8VEH5; -.
DR PRIDE; Q8VEH5; -.
DR ProteomicsDB; 275633; -.
DR Antibodypedia; 28166; 403 antibodies from 28 providers.
DR DNASU; 77781; -.
DR Ensembl; ENSMUST00000060711; ENSMUSP00000052904; ENSMUSG00000046785.
DR Ensembl; ENSMUST00000135807; ENSMUSP00000120245; ENSMUSG00000046785.
DR GeneID; 77781; -.
DR KEGG; mmu:77781; -.
DR UCSC; uc009rvr.1; mouse.
DR CTD; 9852; -.
DR MGI; MGI:1925031; Epm2aip1.
DR VEuPathDB; HostDB:ENSMUSG00000046785; -.
DR eggNOG; ENOG502QS6T; Eukaryota.
DR GeneTree; ENSGT00950000182812; -.
DR HOGENOM; CLU_021316_5_1_1; -.
DR InParanoid; Q8VEH5; -.
DR OMA; HGERING; -.
DR OrthoDB; 788135at2759; -.
DR PhylomeDB; Q8VEH5; -.
DR TreeFam; TF328297; -.
DR BioGRID-ORCS; 77781; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Epm2aip1; mouse.
DR PRO; PR:Q8VEH5; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VEH5; protein.
DR Bgee; ENSMUSG00000046785; Expressed in ventromedial nucleus of hypothalamus and 223 other tissues.
DR Genevisible; Q8VEH5; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0098554; C:cytoplasmic side of endoplasmic reticulum membrane; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0005978; P:glycogen biosynthetic process; IMP:MGI.
DR GO; GO:2000467; P:positive regulation of glycogen (starch) synthase activity; IMP:MGI.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:MGI.
DR GO; GO:0032868; P:response to insulin; IMP:MGI.
DR InterPro; IPR026630; EPM2A-int_1.
DR InterPro; IPR040647; SPIN-DOC_Znf-C2H2.
DR PANTHER; PTHR45913; PTHR45913; 1.
DR Pfam; PF18658; zf-C2H2_12; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Phosphoprotein; Reference proteome.
FT CHAIN 1..606
FT /note="EPM2A-interacting protein 1"
FT /id="PRO_0000086993"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 606 AA; 70096 MW; 8D0F88686866D953 CRC64;
MWMTPKRIRM EVDEALVFRP EWTQRYLVVE PAEGDGALCL VCRRLVASTR ERDVRRHYEA
EHEFYERFVG DEERAALVER LRQGDMSLAA VLTPEERATR AGLGLCRFLA LKGRGWGEGD
FVHQCMEVLL REVLPDHVGV LEGIDLSPEI TRQRILSIDS NLRSQLFNRA RDFKAYSLAL
DDQAFVAYEN YLLVFIRGVG RDLEVQEDLL TIINLTHHFS VGALMSAILE ALQTAGLSLQ
RMVGLTTTHT LRMIGENSGL VSYMREKAVS PNCWNVIHYS GFLHLELLSS YDVDINQIIN
TISEWVVMIK TRGVRRPEFQ PLLTESESEH GERVNGRCLN NWLRRGKTLK LIFSLRKEIE
AFLVSVGATT VHFSDKQWLC DFGFLVDIMD YLREISEELQ ISKVFAAAAF ERICTFEGKL
SSLQRHMEEV NLTDFPAFSI IVDELKQQFK EDQKIFDPDR YQMVISRLQK DFERHFKDLR
FIKKDLELFS NPFSFKPEYA PISVRVELTK LQANTDLWNE YRVKDLGQFY AGLSGEAYPI
IKGVAYKVAS LFDSNQICDK AFAYLTRNQH TLSQPLTDEH LQALFRVATT EMDPRWDDLV
RERNDS
